Tumour Pathology 2

Question 1

Caner alters genetics by

Answer 1

Decreasing TSG

Increasing oncogenes

Question 2

Cancer alters cellular function by releasing _________ proteins, _______ cell-to-cell adhesion and altered cell-to-_________ adhesion

Answer 2

1. tumour related pr
2. decreasing
3. matrix (move tumour)

Question 3

Cancer has abnormal morphology as cellular + nuclear ___ occurs and _____ is abnormal

Answer 3

1. pleomorphism

2. mitoses

Question 4

Cancer cells are capable for ______ growth

Answer 4

independant

Increased angiogenesis - increased blood vessels - decreased prognosis

Decreased apoptosis

Question 5

alpha-feto protein is present in:

Answer 5

testis teratoma and hepatocellular carcinoma

Question 6

Carcino-embryonic Ag (CEA) in

Answer 6

colon cancer (monitoring)

Question 7

Oestrogen receptor and Her2 in

Answer 7

breast cancer

Question 8

Increased apoptosis leads to ______ susceptibility to chemo/radiotherapy

Answer 8

Increased

Question 9

Spread to surrounding tisc

Answer 9

invasion

Question 10

Spread to another organ

Answer 10

metastasis

Question 11

Pleural, Peritonial cavities, Lung, colon and ovaries spread by:

Answer 11

trans-coelomic

Question 12

Common sites of metastasis

Answer 12

Liver, lung, brain, bone - axial and adrenal gland

Question 13

Uncommon sites of metastasis

Answer 13

heart, kidney, spleen and skeletal muscle (normally receive large amount of blood flow.

Question 14

Breast tumour commonly metastasise to:

Answer 14

bone, liver

Question 15

Prostate tumour commonly metastasise to:

Answer 15

bone

Question 16

Colon tumour commonly metastasise to:

Answer 16

liver