Drug Elimination

Question 1

Irreversible removal of drug from the body

Answer 1

Elimination

Question 2

Primary organ for excretion

Answer 2

Kidney (nephron)

hepatobiliary - liver excrete metabolised drug into bile =in faeces e.g. rifamcipin (antibiotic)

Question 3

(urine[Drug] x urine vol) /[plasma[drug]

Answer 3

clearance (ml/min)

how much drug cleared in a given time

Question 4

Low GFR = Low Urine vol = kidney disease = low clearance

T or F?

Answer 4

T

Question 5

Drug secretion into filtrate/renal tube = ————— urine [drug] and ———— Clearance

Answer 5

Increased urine [drug] and increased Clearance

Question 6

In GFR, all ___________ drugs are filtered except _____ size

Answer 6

Unbound drugs
Large size
GFR - 190L fluid filtered/day

Question 7

1. Only un-ionised drugs such as weak acid reabsorbed

2. affected my RF

Answer 7

Passive Tubular filtration/resorption

Question 8

1. Some drug actively secreted into proximal tubule (acidic/basic compounds)
2. Imp for eliminating protein bound cationic/anionic drugs

Answer 8

Active Tubular filtration/secretion

Question 9

Damaged liver - ________ rate of conjugate/biliary secretion and ___________ build up/resorption = _______ toxicity

Answer 9

Decreased rate
Increased resorption
Increased toxicity

Question 10

Resorption from bile to circ is called ________

Answer 10

Enterohepatic circ

Metabolised drug - secreted into bile; Most eliminated; some reabsorbed into Enterohepatic circ - continuous cycle until drug metabolised in liver/excreted in urine

Question 11

Is conjugate drug reabsorbed from small intestine?

Answer 11

No