Imaging in Cancer Flashcards
conventional diagnosis
endoscopy/biopsy and barium
w/o aid of computer
radio-opaque contrast used for outlining GI
Barium Sulphate
high atomic no of barium absorbs more xray photons than other tisc - white on radiograph
barium swallow and meal
oesophagus , stomach and duodenum
barium follow through
small bowel
fast for 4-6 hrs
barium enema
large bowel
low residue diet for 48 hours and bowel cleaning with Picolax
Barium is limited than Endoscopy as … cannot be taken
biopsy
double barium contrast is more than single as it doesn’t
obstruct the view of surrounding tissue
…… is a modern version of barium enema
CT colonoscopy
Which has higher radiation dose - barium meal or enema?
Barium enema - 7 mSv
meal - 1.5 mSv
cross sectional imaging includes
CT, MRI, PET
Xrays produce image of slice of tisc usually in an axial place using computing to create image
Computed tomography
CT
CT image reconstructed when …. decay/absorbed depending on density
photons
attenuation of values of voxels are expressed as a CT no. which relates the attenuation value to that of water
Hounsfield Unit (HU)
(air -1000; bone +3000; water 0)
Bone most dense
gastrografin
oral CT contrast agent (dilute iodine based)
outline GI -but less common - better resolution in new gen scanners
used for elderly if enema & CT colonscopy not possible
omnipaque
IV CT contrast agents - iodine based - injected into veins to demonstrate blood vessels or the vascularity of diff tisc
occasionally allergy and anaphylactic reaction occur using this contrast
IV (CT) contrast - iodine based (Omnipaque)
Diagnosis and staging of cancer is dependent on
- depth of penetrance of tumour
- position
- involvement of regional lymph nodes
- presence of distant metastases
- relationship to adjacent structures
what scan used for Identifying metabolism?
PET
so not used for liver, background disruption as it has high metabolism - so
The object has to be stationary for these scans to be effective
MRI
CT
….. not effective for airy areas (least dense)/less tisc
MRI
Spinal cord, CNS and MSK visualised by
MRI
these structures are small to be detected by CT
CT Radiation dose for abdomen and pelvis
-10mSv
CT Radiation dose for chest
-8 mSv
ALARA principle
examination necessary?
enough clinical info and appropriate protocol?
avoid rpt examinations
Strong magnetic field aligns protons(H+) and this is measured by
MRI
magnetic force unit - tesla
Radiofrequency pulse displaces …… and images created by displaying time taken for ……. to ….. back to the original alignment.
1 and 2: protons
- relax
Water - very light - rotate long time
Fat - heavy - rotate less time
MRI Indications
- bone soft tisc detail
- vessels
- brain, spine and MSK
- abdo and pelvis
- cardiac
MRI disadvantage
claustrophobic and noisy
motion artefact
cannot image patients with pacemakes and aneurysm clips
gadolinium DTPA
IV contrast
easily see vascular lesions and some tumours
NHS screening for:
BBC
Breast - Mammogram
Bowel
Cervix - PAP smear