Tumor suppressor genes Flashcards

1
Q

BRCA1/2

A

DNA repair gene. Breast and Ovarian Cancer

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2
Q

APC/ beta catenin

A

Wnt signaling pathway: Colon, gastric, pancreatic cancer. Familial adenomatous polyposis.

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3
Q

TP53

A

Genomic instability. Most Cancers. Li-Fraumeni syndrome

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4
Q

RB

A

G1/S transition inhibitor: Retinoblastoma, Osteosarcoma

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5
Q

WT1

A

Urogenital differentiation: Wilms tumor

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6
Q

VHL

A

Ubiquitin ligase component: RCC, Von hippel-lindau

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