Tumor suppressor genes Flashcards
1
Q
BRCA1/2
A
DNA repair gene. Breast and Ovarian Cancer
2
Q
APC/ beta catenin
A
Wnt signaling pathway: Colon, gastric, pancreatic cancer. Familial adenomatous polyposis.
3
Q
TP53
A
Genomic instability. Most Cancers. Li-Fraumeni syndrome
4
Q
RB
A
G1/S transition inhibitor: Retinoblastoma, Osteosarcoma
5
Q
WT1
A
Urogenital differentiation: Wilms tumor
6
Q
VHL
A
Ubiquitin ligase component: RCC, Von hippel-lindau