FA Oncogenes

Question 1

Gain of function leads to increased cancer risk; need damage to how many alleles needed?

Answer 1

1

Question 2

BCR-ABL

Answer 2

CML, ALL; Tyrosine Kinase

Question 3

bcl-2

Answer 3

Follicular and undifferentiate lymphomas; anti-apoptotic molecule (inhibits apoptosis)

Question 4

BRAF

Answer 4

Melanoma; Serine/threonine kinase

Question 5

c-kit

Answer 5

Gastrointestinal stromal tumor; cytokine receptor (for stem cell factor)

Question 6

c-myc

Answer 6

Burkitt lymphoma; transcription factor

Question 7

HER2/neu (c-erbB2)

Answer 7

Breast, Ovarian, and Gastric Carcinomas; Tyrosine Kinase

Question 8

L-myc

Answer 8

(L)ung tumor; Transcription factor

Question 9

N-myc

Answer 9

(N)euroblastoma; Transcription factor

Question 10

ras

Answer 10

Colon cancer, lung cancer, pancreatic cancer; GTPase

Question 11

ret

Answer 11

MEN 2A and 2B; Tyrosine Kinase

Question 12

Which have tyrosine kinase activities?

Answer 12

1) ret, 2) HER2/NEU (c-erbB2) 3) BCR-ABL

Question 13

What are the transcription factors?

Answer 13

1) c-myc 2) L-myc 3) N-myc

Question 14

Which is the GTPase?

Answer 14

ras

Question 15

which is the serine/threonine kinase?

Answer 15

BRAF