FA tumor suppressor genes

Question 1

Tumor suppressor genes loss of function increases caner risk;

Answer 1

both alleles must be lost for expression of disease

Question 2

APC gene

Answer 2

Colorectal cancer (associated with FAP)

Question 3

BRCA1

Answer 3

Breast and ovarian cancer; DNA repair protein

Question 4

BRCA2

Answer 4

Breast and ovarian cancer; DNA repair protein

Question 5

CPD4/SMAD4

Answer 5

Pancreatic Cancer; DPC - Deleted in Pancreatic Cancer

Question 6

DCC

Answer 6

Colon Cancer; DCC Deleted in Colon Cancer

Question 7

MEN1

Answer 7

MEN type 1

Question 8

NF1

Answer 8

Neurofibromatosis type 1; RAS GTPase activating protein (neurofibromin)

Question 9

NF2

Answer 9

Neurofibromatosis type 2; Merlin (schwannomin) protein

Question 10

p16

Answer 10

Melanoma; Cyclin-dependent kinase inhibitor 2A

Question 11

p53

Answer 11

Most human cancers, Li-Fraumeni syndrome; Transciption factor for p21, blocks G1-S phase

Question 12

PTEN

Answer 12

Breast, Prostate, Endometrial

Question 13

RB

Answer 13

RetinoBlastoma, osteosarcoma; Inhibits E2F; blocks G1-S phase

Question 14

TSC1

Answer 14

Tuberous sclerosis; Hamartin protein

Question 15

TSC2

Answer 15

Tuberous sclerosis; Tuberin protein

Question 16

VHL

Answer 16

Von Hippel Lindau disease; Inhibits hypoxia inducible factor 1a

Question 17

WT1

Answer 17

Wilms Tumor (nephroblastoma)

Question 18

WT2

Answer 18

Wilms Tumor (nephroblastoma)