Antiprotozoan therapy Flashcards

1
Q

Patient has toxoplasmosis, what is treatment of choice?

A

Pyrimethamine + sulfadiazine

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2
Q

Patient has Trypanosmoa brucei, what is treatment of choice?

A

suramin (blood) and melarsoprol (cns)

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3
Q

Patient has T. cruzi, what is treatment of choice?

A

nifurtimox or benznidazole

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4
Q

Chloroquine mech

A

Block detoxification of heme into hemozoin. Heme accumulates and is toxic to plasmodia

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5
Q

Chloroquine is used to treat all plasmodium species except which one? why? how?

A

P. falciparum; frequency of resistance too high; membrane pump that decreases intracellular concentration of drug.

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6
Q

What is the treatment of P. Falciparum?

A

artemether/lumefantrine OR atovaquone/proguanil.

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7
Q

Treatment for giardiasis?

A

Tinidazole or metronidazole

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7
Q

Treatment for giardiasis?

A

Tinidazol

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8
Q

Treatment for entamoeba histolytica

A

Metronidazole, iodoquinol for asymptomatic cyst passers

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9
Q

Treatment for cryptosporidium

A

Prevention by filtering city water supplies. Nitazoxanide in immunocompetent hosts

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10
Q

Treatment for naegleria fowleri

A

Amphotercin B

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11
Q

Leishmania donovani

A

Amphotericin B, sodium stibogluconate

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12
Q

Babesia

A

Atovaquone + azithromycin

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13
Q

Plasmodium treatment

A

1) Begin with chloroquine, which blocks plasmodium heme polymerase 2) if resistant use mefloquine or atovaquone/proguanil 3) if life threatening use IV quinidine (test for G6PD deficiency) 4) for P vivax/ovale: add primaquine for hypnozoite (test for G6PD deficiency)

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