MEN syndromes

Question 1

What are the characteristics of MEN1? (Wermer Syndrome)?

Answer 1

1) Parathyroid tumors 2) Pituitary tumors (prolactin or GH) 3) Pancreatic endocrine tumors (zollinger ellison syndrome, insulinomas, VIPomas, glucagonomas

Question 2

What is the mneumonic for MEN1?

Answer 2

The 3 P’s: Parathyroid, Pituitary, Pancreas

Question 3

MEN 2A (Sipple Syndrome) characteristics?

Answer 3

1) Medullary thyroid carcinoma (secretes calcitonin) 2) Pheochromocytoma 3) Parathyroid hyperplasia

Question 4

mneumonic for MEN2A

Answer 4

2 P’s: Parathyroids and pheochromocytoma

Question 5

MEN2B characteristics?

Answer 5

1) Medullary thyroid carcinoma (secrtes calcitonin) 2 Pheochromocytoma 3) Oral/intestinal ganglioneuromatosis (mucosal neuromas) 4) Associated with marfanoid habitus

Question 6

ret gene mutation is associated with which men’s ?

Answer 6

MEN2A and MEN2B

Question 7

MEN syndromes autosomal dominant or recessive?

Answer 7

AD