Rate-Limiting Enzymes of metabolic processess

Question 1

Glycolysis

Answer 1

PFK-1 (+ AMP, + Fructose-2,6 bisphosphate, - ATP, -Citrate

Question 2

Gluconeogenesis

Answer 2

Fructose-1,6-bisphospatase (+ATP, +acetyl-coA, -AMP, -fructose-2,6bisphosphate)

Question 3

TCA cycle

Answer 3

Isocitrate DH (+ADP, -ATP, -NADH)

Question 4

Glycogenesis

Answer 4

Glycogen synthase (+glucose-6-phosphate, +insulin, +cortisol, -epinepherine, -glucagon)

Question 5

Glycogenolysis

Answer 5

Glycogen phosphorylase (+epinepherine, +glucagon, +AMP, -glucose-6-phosphate, -insulin, -ATP)

Question 6

HMP shunt

Answer 6

Glucose-6-phosphate DH (+ NADP, - NADPH)

Question 7

De novo pyrimidine synthesis

Answer 7

Carbamoyl phosphate synthetase

Question 8

De novo purine synthesis

Answer 8

Glutamine-phosphoribosylpyrophosphate (PRPP) amidotransferase (-AMP, - inosine monophosphate (IMP), -
GMP)

Question 9

Urea Cycle

Answer 9

Caramoyl phosphate synthetase I (+ N-acetylglutamate)

Question 10

Fatty acid synthesis

Answer 10

Acetyl-CoA carboxylase (+ insulin, + citrate, - glucagon, - palmitoyl-CoA)

Question 11

Fatty acid oxidation

Answer 11

Carnitine acyltransferase I (- Malonyl-CoA)

Question 12

Ketogenesis

Answer 12

HMG-CoA synthase

Question 13

Choleterol synthesis

Answer 13

HMG-CoA reductase (+ insulin, + thyroxine, - glucagon, -cholesterol)