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Pulmonary Midterm > Tricyclic Amines > Flashcards

Tricyclic Amines Flashcards

1
Q

General rules

A

Dose reduction needed to Renal pts

NOT safe in pregos

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2
Q

MOA

A

Block M2 proton ion channel of virus particle and inhibit uncoating of viral RNA within infected host cells, preventing replication

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3
Q

Spectrum

A

A

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4
Q

Resistance

A

High resistance rates in H1N1 and H3N2

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5
Q

Amantadine

A

Well absorbed, 67% protein bound

Behavioral changes, hallucinations, seizures

Excreted in urine

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6
Q

Rimantadine

A

4-10X more effective than other drug in vitro

40% protein bound

Longer half life

Dose reduction needed in liver pts

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Pulmonary Midterm (16 decks)

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