NNRTIs

Question 1

MOA of class

Answer 1

Bind directly to HIV-1 reverse transcriptase—> allosteric inhibition of RNA and DNA-dependent DNA polymerase activity

Question 2

Older drugs

Answer 2

Delavirdine

Efavirenz

Nevirapine

Question 3

Newer ones (2nd gen)

Answer 3

Etravirine

Rilpivirine

Question 4

Adverse effects as class

Answer 4

GI

Rash (serious if happens)

CYP450- many DDI

Question 5

Efavirenz

Answer 5

Later pregos**

Long 1/2 life

CNS side effects- stop drug if pt dreams of axe wielding elf named viren

Question 6

Ertavirine

Answer 6

Overcomes resistance of 1st gen

Rash/n/diarrhea

Lots of DDI (CYP3A4 and 2C9)

Question 7

Nevirapine

Answer 7

Single dose given at onset of labor and another to baby within 3 days- prevent transmission (50-75% effective)

Rash- maculopapular, spares palms/soles

Liver toxicity - women, higher CD4 count, esp with HBV/HCV

Question 8

Rilpivirine

Answer 8

+ Emtricitabine + tenofovir = once daily tablet

Pregos**

No DDI ID w/ other anti-retroviral agents