PIs

Question 1

MOA of class

Answer 1

Block HIV protease and prevent maturation of final structural proteins that make up mature viron core

Results in less mature cells easier to kill

Question 2

Adverse effects of class

Answer 2

Redistribution and accumulation of body fat (breast enlargement and stomach obesity)

Question 3

All end in

Answer 3

Navir

Question 4

Atazanivir

Answer 4

Pregos- if boosted***

Once daily

Indirect hyperbilirubinemia w/jaundice- d/t non-specific inhibition (UG1A1)

Question 5

Darunavir

Answer 5

Pregos**

Must be given w/ ritonavir or cobicistat (boosters)

Don’t give with sulfa allergies

Question 6

Fosamprenavir

Answer 6

Prodrug of amprenavir (has longer half life)

Sulfa allergy**

Rash-stop drug

Question 7

Indinavir

Answer 7

Kidney stones** -drink lots of H2O to prevent this

Boost w/ ritonavir- 2X daily dose, but increases risk of kidney stones, so drink more

Question 8

Lopinavir

Answer 8

Pregos** **

Give with ritonavir- doesn’t stick around long enough on its own

Question 9

Nelfinavir

Answer 9

Diarrhea/flatulence

Diarrhea may be dose limiting because it can be so bad

Question 10

Ritonavir

Answer 10

BOOSTER**

Not used by itself b/c high rate GI issues, use as booster in low doses- inhibits CYP450

Question 11

Saquinavir

Answer 11

Minimal absorbed orally

Boost w/ rit- less dyslipidemia or GI issues

Question 12

Tipranavir

Answer 12

Recent addition (2005)

Use in pts resistant to other PIs

Boost w/ Rit

Sulfa allergy* dont use