Entry Inhibitor

Question 1

MOA

Answer 1

Bonds specifically to CCR5 to prevent viral entry into host cell.

Throwing rocks at virus preventing it from binding to receptor

Question 2

Maraviroc

Answer 2

Oral drug

Don’t use in Renal failure

Can cause hepatic toxicity- discontinue

Question 3

Resistance

Answer 3

Mutations in V3 loop of gp120 and CCR4 bonding virus

Question 4

Test for what?

Answer 4

Co-receptor tropism

If using CVR4 to enter cell, won’t work much