Methylxanthines C/A

Question 1

MOA

Answer 1

Inhibit PDE enzyme family increasing concentrations of intracellular cAMP

Inhibition of cell surface receptors for adenosine

Enhance histone deacetylation

Question 2

Theophylline

Answer 2

Rarely used alone (use w/ B agonist)

Narrow therapeutic index (monitor)

DDI

Bronchodilaton

Question 3

Caffeine

Answer 3

Bronchodilation (lrg doses needed)

Given a lot in NICU

Can cause CNS affects