Antimuscarinic Agents C/A

Question 1

MOA

Answer 1

Competitively inhibit action of ach at muscarinic receptors

Blocks prod of mucous and causes bronchodilation

Question 2

Atropine

Answer 2

Limited by absorption into circulation and across BBB (can have off target effects)

Datura stramonium- Indian plant it was discovered from

Question 3

Ipratropium

Answer 3

Charged derivative of atropine- free of systemic adverse effects

Stays in lungs if inhaled

Question 4

Tiotropium and aclidinium

Answer 4

Longer acting, approved for COPD, not for maintenance of asthma**

Tio - 24 hrs and acl- 12 hrs