Anti Flu- Neuroaminidase Inhibitors Flashcards by Abbie Heaton | Brainscape

Q

MOA

A

Competitively and reversibly interact at BS to inhibit viral neuroaminidase activity —> clumping or flu virgins to each other and membrane of cells

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Q

Spectrum

A

A and B

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Q

Oseltamivir

A

Neuropsychiatric events (self harm or delirium)

Given orally

Half life 6-10 hrs

Available IV

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Q

Zanamivir

A

Given via inhalation

Adverse- cough, bronchospasm, nasal and throat discomfort, decrease in pulm function

Available IV

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Q

Peramivir

A

Used to treat H1N1 in 2009

Not approved in US otherwise

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Q

When to give these drugs?

A

Early in illness, which virus still replicating (first couple days)

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