Leukotriene Pathway Inhibitors C/A Flashcards by Abbie Heaton | Brainscape

Q

Zileuton

A

Inhibit 5-lipoxygenase

Cause liver toxicity

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Q

Zafirlukast and montelukast

A

Inhibit binding of LTD4 to receptor

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Q

Benefit in kids?

A

Can be given orally instead of inhaled

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Q

Most prescribed?

A

Mont- approved as young as 12 months

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Q

AERD

A

Very small dose aspirin=

Bronchoconstriction (profound)

Flushing, abdominal cramping

Nasal congestion

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Q

Drugs that reduce response to aspirin challenge:

A

Zafirlukast and montelukast

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