Fungi- Azoles Flashcards
1
Q
MOA class
A
Inhibit fungal CYP450- lowers ergosterol synthesis and prevents formation of viable cell wall
Broad spectrum
2
Q
Ketoconazole
A
Only amitrozole
Tends to inhibit CYP450 non-selectively —> more adverse effects
3
Q
Itraconazole
A
Poor penetration into CSF
Been replaced by voriconazole as drug for aspergillus
4
Q
Fluconazole
A
Good CSF penetration
Less DDI
Widest therapeutic agent of class- used as profil treatment in BM transplant pts and AIDS
Crypto** , mucor**
5
Q
Voriconazole
A
Inhibits mammalian CYP3A4 (increase dose of other meds if given together)
Treats aspergillus**
Visual disturbances (blurry) -goes away after 30 mins
6
Q
Posaconazole
A
Liquid only
Broadest spectrum
Candida and aspergillus
Only one that gets mucor**
BM transplant drug
