NRTIs

Question 1

MOA of class

Answer 1

Competitive inhibition of HIV-1 reverse transcriptase. Allows drug to be put into viral DNA chain —> immature termination & inhibition

Question 2

Adverse effects of class

Answer 2

Mitochondrial toxicity

Question 3

Abacavir

Answer 3

Get serum levels if alcoholic

Hypersensitivity in first 6 weeks, skin rash

If hypersensitive- don’t give again, can kill pt

Question 4

Didanosine

Answer 4

Dose dependent pancreatitis

Retinal changes and optic neuritis- get exams regularly

Question 5

Emtricitabine

Answer 5

Pregos**

Long half life

Hyperpigmentation of palms/soles of feet esp in AA

HBV**

Question 6

Lamivudine

Answer 6

Treats HBV- stopping may cause exacerbation of HBV

Pregos**

Question 7

Stavudine

Answer 7

Dose dependent peripheral sensory neuropathy

Pancreatitis too, watch in pts w/ liver probs

Question 8

Tenofovir

Answer 8

Pregos** nucleotide** (others sides)

HBV

Tenofovir alafenamide- prodrug, less renal toxicity, treats HBV

Question 9

Zidovudine

Answer 9

Pregos**

First agent approved, well studied

Side effects resolve during therapy (insomnia unique one)