treatment of viral disease Flashcards
summarise the general strategy of designing drugs which target infectious agents but not the patient’s own cells, and identify stages in the life cycle of viruses which could potentially allow therapeutic intervention
1
Q
define prophylaxis
A
preventing disease before aetiologic agent is required by vaccination or giving drug before infection
2
Q
define therapy
A
treating disease after host is infected
3
Q
what is required for a rational drug design
A
understanding structure of viral components and enzymes to design drugs to target them e.g. RTase unique to virus so safe to target
4
Q
influenza virus replication drugs
A
targets: sialidase or neuraminidase by inhibition; tamiflu, relenza and baloxavir - targets PA endonuclease, stopping mRNA replication
5
Q
HIV retroviral therapy
A
targets: many drugs in combination so multiple mechanisms of action; reverse transcriptase only in HIV so safe to target
6
Q
HepC antiviral therapy
A
ribavirin interferon treatment
