transplant immunosuppression 1 Flashcards
1
Q
what immunosuppressive drugs kill all T Cells; wiping out entire adaptive immune response
A
Depleters:
Thymoglobulin (ATG)
Antithimocyte globulin (ATGAM)
Alemtuzumab
2
Q
What is the MOA of methylprednisolone
A
decreases IL-2 production
inhibits IL-2 receptor expression
inhibits macrophage MHC expression
3
Q
What is the MOA of Basiliximab
A
IL-2 antagonist, blocks IL2 receptor
4
Q
why is basiliximab preferred over polyclonal antibodies
A
less side effects (basiliximab is a monoclonal antibody)
5
Q
What is the MOA of antithymocyte globulins such as ATG
A
deplete circulating lymphocytes through direct cytotoxicity towards T cells
6
Q
What are the adverse effects of ATG?
A
fever, chills, and malaise due to cytokine release syndrome
