Stem Cell Transplant

Question 1

why are stem cell transplants given in chemo patients?

Answer 1

bone marrow suppression limits chemotherapy; HSCT allows for bone marrow replenishment so higher doses of chemo can be given

Question 2

what are indications for autologous stem cell transplants

Answer 2

1. multiple myeloma
2. some non-hodgkins lymphoma
3. hodgkins disease
4. neuroblastoma
5. germ cell tumors

Question 3

what are the indications for allogeneic stem cell transplant (cancer related on)

Answer 3

1. leukemia
2. lymphoma
3. myelodysplastic syndrome

Question 4

what percent of bone marrow cells are hematopoietic stem cells

Answer 4

0.01%

Question 5

what drug can mobilize peripheral blood stem cells but doesn’t cause them to proliferate?

Answer 5

mozobil (plerixafor)

Question 6

how many stem cells are needed for a transplant

Answer 6

between 2 to 5 million stem cells/ kg

Question 7

what are some stem cell transplant complications

Answer 7

1. mucositis, n&v
2. infections
3. pulmonary complications
4. sinusoidal obstruction syndrome (SOS)
5. GVHD

Question 8

what are some stem cell transplant complications

Answer 8

1. mucositis, n&v
2. infections
3. pulmonary complications
4. sinusoidal obstruction syndrome (SOS)
5. GVHD

Question 9

what is the dose limiting toxicity for melphalan

Answer 9

mucositis

Question 10

what are 3 very common drugs given for infection prophylaxis with a stem cell transplant

Answer 10

1. fluconazole
2. acyclovir
3. levofloxacin

Question 11

what is GVHD

Answer 11

graft versus host disease; donor t-cells attack the host

Question 12

what must be given to allogeneic stem cell transplant patients to prevent GVHD

Answer 12

1. tacrolimus
2. steroids
3. . methotrexate

Question 13

how is GVHD treated

Answer 13

high dose methylprednisolone