cancer 2 Flashcards
what is the length of the tumor cell cycle known as?
doubling time
what is the proportion of actively dividing tumor cells known as?
growth fraction
Typically how many tumor cells are needed for a diagnosis of cancer
10^9
what is the tumor burden
number of cancer cells, size of tumor and amount of cancer in the body
what is the cell-kill hypothesis
a certain percentage of cancer cells will be killed with each course of chemo (independent of number of tumor cells)
what is a schedule dependent chemotherapy agent
cell cycle phase specific chemotherapy
what types of cancers have screening guidelines
breast
colon
prostate
cervical
what are the 7 warning signs of cancer
- Change in bowel or bladder habits
- A sore throat that will not heal
- Unusual bleeding or discharge
- Thickening or lump in breast
- Indigestion or difficulty swallowing
- Obvious change in a wart or mole
- Nagging cough or hoarseness
what is the TNM Staging system
Tumor, Node, Metasteses staging
t1-t4), (n0-n3), (m0-m1
What are the stages of cancer
stage I - localized tumor
Stage II and III - local and regional extension of disease
Stage IV - Presence of distant metasteses
what are the grades of the ECOG performance status and what does it mean
0 = fully active 1 = restricted in strenuous activity 2 = awake and does self care but no work 3 = capable of only limited self care, confined to bed or chair 50% of waking hours 4. completely disabled 5. dead
what are the grades of the ECOG performance status and what does it mean
0 = fully active 1 = restricted in strenuous activity 2 = awake and does self care but no work 3 = capable of only limited self care, confined to bed or chair 50% of waking hours 4. completely disabled 5. dead
what are the grades of the ECOG performance status and what does it mean
0 = fully active 1 = restricted in strenuous activity 2 = awake and does self care but no work 3 = capable of only limited self care, confined to bed or chair 50% of waking hours 4. completely disabled 5. dead
