transplant 3

Question 1

what is the first line treatment option for acute cellular rejection

Answer 1

methylprednisolone followed by prednisolone taper

Question 2

what is second line treatment option for acute cellular rejection. Used for steroid resistant rejection

Answer 2

polyclonal antibodies: ATG or ATGAM

Question 3

what is used to minimize adverse reactions to polyclonal antibodies

Answer 3

pretreatment with corticosteroids, Tylenol, or benadryl

Question 4

what strategy is often use to reverse humoral rejection?

Answer 4

plasmapheresis, often in combination with intravenous immunoglobulin

Question 5

List the 7 different treatment options for humoral rejection (vascular rejection)

Answer 5

1. Plasmapheresis with IVIG
2. Plasmapheresis (alone)
3. High-dose IVPB methylprednisolone
4. Antithymocyte globulin
5. Cyclosphosphamide
6. Rituximab
7. Bortezomib

Question 6

what are the treatment options for chronic rejection

Answer 6

none; not reversible

Question 7

what are the primary tissues and organs of the immune system?

Answer 7

1. bone marrow - where T cells are made
2. Thymus - where T cells mature
3. Spleen - reserve of red blood cells
4. lymph nodes - filters cells out of the body