hematologic malignancies 2

Question 1

what type of leukemia is most common in children

Answer 1

acute lymphocytic leukemia (ALL)

Question 2

what are the signs and symptoms of acute lymphocytic leukemia

Answer 2

no urgent symptoms
anemia
CNS symptoms
neutropenia (infection)
blood chemistry findings
splenomegaly, hepatomegaly, and lymphadenopathy

Question 3

what are poor prognostic factors for acute lymphocytic leukemia (ALL)

Answer 3

WBC over 50,000
chromosome abnormalities
males
younger than 1 or older than 10
no remission in first 4 weeks of treatment

Question 4

treatment of acute lymphocytic leukemia (ALL) must include what type of prophylaxis

Answer 4

CNS prophylaxis; drugs must cross BBB

Question 5

what is the low risk induction treatment for children with acute lymphocytic leukemia (ALL)?

Answer 5

vincristine + corticosteroid + pegaspargase

Question 6

What is the high risk induction treatment for children with acute lymphocytic leukemia (ALL)?

Answer 6

vincristine + corticosteroid + pegaspargase + daunorubicin

Question 7

what should be added for induction treatment of adults with lymphocytic leukemia (ALL) and Ph+ disease

Answer 7

imatinib

Question 8

what should be added for induction treatment of adults with lymphocytic leukemia (ALL) and CD20+ disease

Answer 8

rituximab

Question 9

what drugs can be used for lymphocytic leukemia (ALL) maintenance

Answer 9

methotrexate weekly
mercaptopurine PO
vincristine
corticosteroids

Question 10

what drugs can be used for CNS prophylaxis for lymphocytic leukemia (ALL)?

Answer 10

intrathecal methotrexate
intrathecal cytarabine
intrathecal hydrocortisone

Question 11

what drugs can be used for CNS prophylaxis for lymphocytic leukemia (ALL)?

Answer 11

intrathecal methotrexate
intrathecal cytarabine
intrathecal hydrocortisone

Question 12

95% of what type of leukemia patients have a Philadelphia chromosome

Answer 12

chronic myelogenous leukemia (CML)