colon cancer

Question 1

what stage of colorectal cancer usually isn’t curable

Answer 1

stage 4

Question 2

for over 40 years what was the only drug that had any benefit for colon cancer

Answer 2

fluorouracil

Question 3

what is the treatment for stage 1 cancer

Answer 3

surgery to remove polyps

Question 4

what is the treatment for stage 2 colon cancer

Answer 4

consider:

1. capecitabine or fluorouracil and leukovorin
2. FOLFOX or CapeOx or FLOX with larger tumors

Question 5

what is the preferred treatment for stage III colon cncer

Answer 5

FOLFOX (category 1) or CapeOx

Question 6

what is in FOLFOX regimen

Answer 6

bolus Fluorouracil
leucovorin
continuous Fluorouracil
oxaliplatin

Question 7

why is oxaliplatin not added to fluorouracil and leukovorin in patients with stage II colon cancer

Answer 7

no survival benefit has been shown to adding oxaliplatin

Question 8

what should be added to 50FU or capecitabine in patients with stage III colon cancer

Answer 8

oxaloplatin

Question 9

True false:

FOLFIRI is superior to 5-FU/LV for colon cancer

Answer 9

false

Question 10

what is in FLOX regimen

Answer 10

bolus Fluorouracil
leucovorin
oxaliplatin

Question 11

what is in FOLFIRI regimen

Answer 11

bolus Fluorouracil
leucovorin
continuous Fluorouracil
irinotecan

Question 12

what is the MOA of leucovorin

Answer 12

stabilizes enzymes enhancing activity of fluorouracil

Question 13

what causes EGFR inhibitor resistanse

Answer 13

KRAS mutation

Question 14

what drugs are EGFR inhibitors

Answer 14

panitumumab

cetuximab

Question 15

what drugs target vascular endothelial growth factor

Answer 15

bevacizumab
ziv-aflibercept
regorafenib

Question 16

what is the oral prodrug of fluorouracil

Answer 16

capecitabine

Question 17

what is the MOA of 5-FU and Capecitabine Associated Diarrhea

Answer 17

causes abnormal absorption and secretion of fluids and electrolytes

Question 18

what can be given with irinotecan to decrease acute diarrhea

Answer 18

atropine