Transplant

Question 1

Graft vs host disease is mediated by ________

Answer 1

T cells (Every year)

Question 2

Hyperacute rejection due to _________

Avoid how?

Answer 2

pre-formed antibodes (avoid by not transplanting when crossmatch is positive)

Question 3

Chronic rejection: mech?; rx?

Answer 3

gradual loss of blood supply; no treatment

Question 4

Immunosuppression is largely ___ and not ____ system; therefore ____ risk

Answer 4

largely cellular and not humoral system, therefore viral risk>bacterial

Question 5

See incr _____ in trasnplant—- what types?

Answer 5

incr CA (skin, leukemia, lymphoma, cervical)

Question 6

1 virus post-transplant

Answer 6

CMV

Question 7

6MP derivative, purine analog that acts as an antimetabolite, decr DNA synthesis

Answer 7

azathioprine

Question 8

blocks purine synthesis to decr T and B cell proliferation

Answer 8

Mycophenolate (cellcept)

Question 9

Inhibits mRNA encoding IL-2. Rotamase inhibitor. Nephrotoxic.

Answer 9

Cyclosporine

Question 10

More potent than cyclosporine, blocks IL-2 expression/production from T cells

Answer 10

FK506

Question 11

Blocks IL-1 from macrophages

Answer 11

Prendisone

Question 12

OKT3 monoclonal antibody, used to treat ______

Answer 12

rejection

Question 13

Biliary stricture post liver transplant, check ________, may be due to ________

Answer 13

check hepatic artery flow, may be due to ischemia

Question 14

1 cause of oliguria s/p renal trasplant

Answer 14

ATN

Question 15

Cardiac transplant: ___% 1 year survival

Answer 15

84%

Question 16

Liver transplant: ___% 1 year graft survival

Answer 16

70% 1 year graft survival