Oncology Flashcards
G1: most _ period of cell cycle. __ act here.
variable; growth factors
Radiation therapy: _ phase most sensitive; most effective with __; higher energy = __; path: __; decreased healing due to: __
M phase; high o2 levels; less skin damage; obliterative enarteritis; impaired fibroblasts
Extremity sarcoma biopsy: excisional if __; otherwise __; incisional biopsy (less __ disruption– easier to excise scar if __)
<4cm; longitudinal incision; lymphatic disruption; biopsy positive (Every year)
Li Fraumeni syndrome: _ mutation _ _ CA _ tumors _
p53 mutation; sarcomas, breast ca; brain tumors; leukemia
Sarcomas generally spread __; not to __. Staging based on _; not on __
hematogenously, not to lymphatics; based on GRADE not size/nodes
Colon Ca associated w: \_\_ \_\_ \_\_ \_\_
loss of APC gene; p53; DCC; k-ras activation
Breast Ca associated w: _ _ _ _ _
p53; BCL-2; C-myc; C-myb; her 2 neu
C- myc associated with:
_
_
_
small cell lung CA; neuroblastoma; burkitt’s lymphoma
BCL-2 gene regulates __;
__ and __ also associated with this process
apoptosis; p53 and c-myc
sis oncogene is homologous to __
PDGF
Erb B codes for ___;
associated with __ survival in breast ca
epidermal growth factor receptor; decreased survival
K ras __ oncogene encodes for __ protein.
__% of pancreatic ca
_% of colon ca
also in __ ca
proto-oncogene; GTP; 90%, 50%; lung
Ret __ oncogene diagnostic for __. Patient with family history of __ who has Ret should have __.
proto-oncogene; Medullary thryoid cancer; MEN; total thyroidectomy
Tamoxifen (binds ___) shown to decrease breast cancer in high risk. Risk of __ with endometrial cancer.
estrogen receptor; DVT
__ and __ both have pulmonary fibrosis as complication.
Bleomycin and Busulfan
