Topic 7: Histology Flashcards
Histology
the study of tissues
Tissue
a group of cells with similar structure and function
List the 4 major tissue types:
Epithelial Tissue; lining tissue
Connective Tissue; connecting tissue
Muscle Tissue; contractile tissue
Nervous Tissue; signalling tissue
Cell Junctions
points of contact between adjacent cells - seen in epithelial tissue, some nervous and muscle cells
formed by cell membrane proteins
List 3 examples of cell junctions
1) Tight Junctions
2) Anchoring Junctions (e.g. desmosomes)
3) Gap Junctions
Tight Junctions
are a partial fusion of specific proteins on the lateral surface of the cell membrane
form ring-like tight seal
prevents material from passing between cells e.g. bacteria, proteins, sometimes
fluid or ions (depending on the tissue)
- things don’t exit or enter
Anchoring Junctions
(e.g. desmosomes)
proteins that fasten cells to each other and/or extracellular material (“rivets” cells
together)
- hold cell close to one another
Gap Junctions
open channels (formed by proteins) through the adjacent cell membranes
interconnecting the cytosols of the cells; allows for interconnected cell
allows ions/small molecules to pass from one cell to another
tissues can then work as a unit:
o important in cardiac and smooth muscle (allows synchronization of
contractions)
o also found in epithelial tissue
Epithelial Tissue
covers body surface
lines body/organ cavities
organ cavity = lumen
Characteristics of Epithelia:
o has one free surface
o little extracellular space between cells; cells are very closely packed
o avascular – no blood vessels
o Basement membrane
Basement membrane
extracellular layer
attaches epithelium to underlying CT layer (formed by both tissues – “velcro”
- Ct layer keeps epithelial tissue alive
What level of organization is the basement membrane?
Organ; b/c 2 tissues
How is epithelial tissue classified
o most subtypes are classified + named according to:
# of cell layers sitting on the basement membrane
shape of the cells in the apical layer (= layer touching the free surface)
one layer
simple
more than one layer
stratified
apical layer
= layer touching the free surface)
squamous
flattened
cuboidal
round or cube shaped
columnar
rectangular
Simple Epithelia
= 1 layer
allow exchange of molecules (gasses, nutrients, etc.)
–absorption/secretion
List the subtypes of simple epithelia
a) simple squamous
b) simple cuboidal
c) simple columnar
simple squamous
= 1 layer of squished (flat) cells
e.g. lungs
simple cuboidal
= 1 layer of cube shaped cells
e.g. kidneys
simple columnar
= 1 layer of column shaped (tall & thin) cells
e.g. stomach, small intestine
Stratified Epithelia
= > 1 layer
protective (areas of abrasion)