Tissues Repair

Question 1

Tissue Repair

Answer 1

1. Inflammation
2. Organization
3. Regeneration

Question 2

Inflammation Process

Answer 2

Isolation via inflammation provides framework for regeneration and two processes overlap.
Signs: swelling, heat, pain
1. Stimulus ( cell damage)
2. Isolate the injury ( release chemicals)
3. Mobilize all cells ( Mast cells are activated)

Question 3

Mast Cells

Answer 3

1. Histamines–> increases blood vessel permeably by making vessels leaky, causes swelling.
2. Prostaglandins
3. Heparin: anticogland ( blood to not clot up)
   Increases blood flow to area, increases temperature, increase blood vessel permeability ( swelling)

Question 4

Mast Cell Effects

Answer 4

Increase in temp. –> increase healing
Increase in permeability–> more oxygen and nutrients
Macrophages destroy bacteria , virus cells

Question 5

Inflammation Steps

Answer 5

1. Injury ( damage)
2. Chemicals released alert mast cells ( - – Prostaglandins–> pain to site
   Histamine–> swelling , increase vessle perm.
3. Increase temp, blood permutability, reaction rate
   - An increase in vessel perm. –> clotting proteins, white blood cells, plasma

Recap:
Injury to cells–> Damaged cell–> mast cells (Histamine, heprain, prosteoglandins)–> Increase blood vessel perm. –> increase in plasma protein, clotting, WBC–> blood clotting forms seal on surface (scab)

Question 6

Isolation to Injury

Answer 6

1. Bleeding Occurs (Injury)
2. Mast cells , white blood cells, clotting proteins, plasma proteins
3. Blood clot dry’s

Question 7

Organization (formation of granulation tissues)

Answer 7

1. Blood Clot is replaced by growth of capillary that restores blood flow. (granulation tissue: temporary connective tissue forms and is replaced by epithelial)
2. Fibroblasts (plasma proteins) build collagen fibers bridge the gap
3. Macrophages: devor dead cells, cell fragments, pathogens (clean up)
4. Epithelial Tissues grow over the granulation tissue

Question 8

Regeneration and Fibrosis

Answer 8

1. Area matures pulling wound closed as collagen fibers shrink.
2. Epithelium divides and thickens under the scab which detaches it
3. Fibrocytes lay down dense regular connective tissue (scar tissue) underneath. Parallel running collagen fibers.