Tissue Nematodes Filaria Flashcards

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1
Q

Convoluted filaria producing Black River Blindness (2nd most common cause of blindness after chlamydia trachomatis)

Hyper and hypopigmented spots with dermatitis

Humans only definitive host

No animal reservoir

Endemic in rivers of tropical Africa and Central America

A

Onchocerca volvulus

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2
Q

Onchocerca infective stage

A

Larvae

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3
Q

Onchocerca intermediate host

A

Blackfly

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4
Q

Onchocerca diagnostic stage

Eosinophilia

A

Microfilariae skin biopsy

Found in skin, lymphatics

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5
Q

Microfilariae in eye cause blindness

Inflammatory nodules in skin

A

Onchocerca volvulus

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6
Q

Onchocerca tx microfilariae

A

Ivermectin

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7
Q

Onchocerca for eye infection

A

Suramin

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8
Q

Sclerosing keratitis

Leopard skin

A

Onchocerca volvulus

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9
Q

Firm, movable, non-tender onchocercal nodule

A

Onchocerca volvulus

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10
Q

Skin reaction that occurs in humans when microfilariae of Onchocerca volvulus in cutaneous site are killed by administration of diethylcarbamazine

A

Mazzoti reaction

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11
Q

Filariasis
Pointed tail free of nuclei

Human infected when female mosquito
Anopheles and culex deposi larvae on skin and infect lymphatics

Causes elephantiasis

A

Wuchereria bancrofti

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12
Q

Adult worms cause inflammation that blocks lymphatic vessels -> edema -> elephantiasis

Lymphadenopathy
Cough from microfilariae in lungs

Eosinophilia

A

Wuchereria

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13
Q

Wuchereria Dx

A

Thick blood smear (taken at night)

Demonstrate microfilariae

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14
Q

Wuchereria tx

A

Diethylcarbamazine

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15
Q
Filariasis bancrofti
Female anopheles, culex
Humans only definitive host
Microfilariae
Blocks lymphatic vessels (elephantiasis)

Tail free of nuclei

A

Wuchereria bancrofti

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16
Q

Malayan lymphatic filariasis

Mosquito vector: Anopheles, Aedes, Culex

More seen in children

More rapid course
Elephantiasis - below knee

A

Brugia malayi

17
Q

Brugia Dx

A

Thick and thin smear at midnight

18
Q

Brugia Tx

A

Diethylcarbamazine

19
Q

Serpent or dragon worm
Copepods containing infective larvae

By ingestion of contaminated water

Migrate to skin produce painful ulcer

Causes peripheral eosinophilia

A

Dracunculus medinensis

20
Q

Dracunculus infective

A

Larvae

21
Q

Dracunculus Diagnostic stage

A

Skin inflammation and ulceration by adult worms

Extraction

22
Q

Dracunculus tx

A

Niridazole

Extraction of worm from skin ulcer

23
Q

Guinea worm disease

A

Dracunculus

24
Q
Eye worm
Calabar swelling (local subcutaneous swelling, transient angioedema)

Humans only definitive host

No animal reservoir

A

Loa loa

25
Q

Loa loa vector

A

Deer fly
Chrysops fly
Tabanid fly

26
Q

Pointed tail containing nuclei

Human infected by bite of deer fly or mango fly

Worm crawling out of conjunctiva
African eye worm

A

Loa loa

27
Q

Swelling around the eyes from Loa loa infection

A

Callabar swelling

28
Q

Loa loa diagnostic

Eosinophilia

A

demonsration of Microfilariae in blood smear

29
Q

Loa loa infective stage

A

Larvae

30
Q

Hypersensitivity causes swelling in skin
Adult worm seen across conjunctiva - granulomata
Painless edema of eyelids with proptosis

A

Loa loa

31
Q

Loa loa tx

A

DEC

32
Q

Both cause cutaneous filariform larva migrans
Creeping reaction
Extremely pruritic

A

Necator americanus

Tx: Thiabendazole

33
Q

Visceral or ocular larva migrans

Ingestion of eggs in food or water contaminated with dog feces

Dogs definitive host

A

Toxocara canis

34
Q

Viscera larva migrans

Parasitic larvae never mature out of larval stage continue to circulate around the body

If it gets to the eye, ocular larva migrans leading to blindness

A

Toxocara canis

35
Q

Granulomas form around dead larvae

Retinal granulomas cause blindness

Dx: larvae in tissue, serologic tests
Eosinophilia

A

Toxocara canis

36
Q

Toxocara canis Tx

A

Mebendazole

Albendazole

37
Q

Cutaneous larva migrans

A

Ancylostoma brasiliense

38
Q

Ancylostoma brasiliense tx

A

Albendazole