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Microbiology > TB > Flashcards

TB Flashcards

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Biology 101 flashcards
1
Q

Rod shaped

0.2 - 0.5 mu in D
2-4 mu in L

A

M tuberculosis

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2
Q

M TB is acid fast because of its

A

Mycolic acid

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3
Q

It resists decolorization with acid and alcohol
Aerobic and non-motile
Multiplies slowly can remain dormant for decades

A

M tuberculosis

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4
Q

Fast grower mycobacterium

A

Mycobacterium fortuitum

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5
Q 
Acid fast
Slow growing
Aerobic 
Produces niacin 
Facultative intracellular
A

M TB

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6
Q

M TB medium

A

Lowenstein-Jensen

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7
Q

Inhibits phagosome lysosome function

A

Sulfatides

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8
Q

Causes serpentine growth in vitro

Inhibits leukocyte migration

A

Cord factor/trehalose dimycolate

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9
Q

CMI delayed hypersensitivity

A

Tuberculin

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10
Q

TB stain

A

Ziel Nielsen Stain detecting long chain mycolic acids

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11
Q

Stain For identification of acid fast bacilli

A

Ziehl Neilsen Stain

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12
Q

Slipping form of TB

A

Parallel

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13
Q

Snapping form of TB

A

V

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14
Q

Niacin +
Catalase -
Grows at 68 deg

A

TB

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15
Q

Serpentine growth

A

TB

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16
Q

Can take up to 6 weeks to identify positive cultures

A

TB

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17
Q

Person-to-person through air by a person with active TB disease of lungs

Inoculation

Transplacental route (very rarely)

A

TB

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18
Q

Most common site of TB

A

Pulmonary TB 80%

Extrapulmonary:
Lymph node
GU
Bones and joints
Meninges
Intestine 
Skin
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19
Q

Most common extrapulmonary site of TB

A

Lymph node

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20
Q

Mycobacterium other than TB that affects lymph node

A

Mycobacterium scrofulaceum

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21
Q

The progression to clinical disease in a previously unexposed immunocompetent person depends on 3 factors

A

Number of M tb inhaled

22
Q

Disease that develops in a previously uninfected person

A

Primary TB

23
Q

Inhaled bacilli implant in the distal air spaces of

A

lower part of upper lobe

Upper part of lower lobe

24
Q

1-1.5 cm area of grey white inflammation with consolidation develops that often

Macrophage
Lymphocyte
Multinucleated giant cells

A

caseates

caseous necrosis

25
Q

Bactermia with seeding of multiple sites result from

A

Natural Resistance Associated Macrophage Protein1 (NRAMP1) polymorphism

26
Q

after 3 weeks, activation of macrophage lead to formation of

A

Epitheloid granuloma hypersensitivity

27
Q

TST is a type of

A

Type IV Delayed hypersensitivity reaction

28
Q

Assay that detects MTBC and resistance to Rifampin

A

Xpert MTB/RIF

29
Q

Uses DNA strip that allows simultaneous molecular identification of TB and the most common genetic mutations causing resistance to Rifampicin and Isoniazid

Provides result in 5 hours

A

Line Probe Assay

30
Q

Used for rapid identification of TB

A

Buffy coat

31
Q

Most common form of MTB

A

Pulmonary

32
Q

Responsible for caseous necrosis in TB

A

Phosphatides

33
Q

Classical tubercular lesion

Granuloma with typical epitheloid cells, lymphocytes fibrosis and

A

Langhan’s giant cells

34
Q

Provides a definitive diagnosis for active tuberculosis

Used to monitor progress of patients while on treatment

Confirm cure at the end of treatment

A

Direct Sputum Smear Microscopy

35
Q

Abnormalities often seen in xray

A

apicolordotic view

36
Q

Subpleural granuloma

A

Ghon’s focus

37
Q

Subpleural granuloma + associated LN

A

Ghon’s complex

38
Q

Usual site of primary TB

A

Middle to lower lobe

39
Q

Usual site of reactivation tuberculosis

A

Apex of the lungs

40
Q

Extrapulmonary TB

A

Renal
Colon
Spine

41
Q

TB of spine/bone

A

Pott’s

42
Q

Children most commonly affected vertebrae

A

Thoracic

43
Q

Adult most commonly affected vertebrae

A

Lower thoracic

Upper lumbar

44
Q

Present with skip lesions
Cobble stone appearance
Caseation

A

TB Colon

45
Q

Present with skip lesions
Cobblestone apearance
Noncaseating

A

Crohn’s

46
Q 
Low grade fever
Night sweats
Weight loss
Fatigue
Cough and hemoptysis
A

TB

47
Q

TB cachexia is caused by

A

TNF alpha

Cachectin

48
Q

Delayed hypersensitivity Type IV skin test to assay

Cel mediated immunity

Read reaction 48-72 h

Induration is considered + if 10 mm

A

PPD

Mantoux test

49
Q

PPD + reading for immunocompromised (HIV)

A

> 5mm

50
Q

+ TST indicates

A

Exposure to organism

Does not indicate active disease

Microbiology (16 decks)

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