TB

Question 1

Rod shaped

0.2 - 0.5 mu in D
2-4 mu in L

Answer 1

M tuberculosis

Question 2

M TB is acid fast because of its

Answer 2

Mycolic acid

Question 3

It resists decolorization with acid and alcohol
Aerobic and non-motile
Multiplies slowly can remain dormant for decades

Answer 3

M tuberculosis

Question 4

Fast grower mycobacterium

Answer 4

Mycobacterium fortuitum

Question 5

Acid fast
Slow growing
Aerobic 
Produces niacin 
Facultative intracellular

Answer 5

M TB

Question 6

M TB medium

Answer 6

Lowenstein-Jensen

Question 7

Inhibits phagosome lysosome function

Answer 7

Sulfatides

Question 8

Causes serpentine growth in vitro

Inhibits leukocyte migration

Answer 8

Cord factor/trehalose dimycolate

Question 9

CMI delayed hypersensitivity

Answer 9

Tuberculin

Question 10

TB stain

Answer 10

Ziel Nielsen Stain detecting long chain mycolic acids

Question 11

Stain For identification of acid fast bacilli

Answer 11

Ziehl Neilsen Stain

Question 12

Slipping form of TB

Answer 12

Parallel

Question 13

Snapping form of TB

Answer 13

V

Question 14

Niacin +
Catalase -
Grows at 68 deg

Answer 14

TB

Question 15

Serpentine growth

Answer 15

TB

Question 16

Can take up to 6 weeks to identify positive cultures

Answer 16

TB

Question 17

Person-to-person through air by a person with active TB disease of lungs

Inoculation

Transplacental route (very rarely)

Answer 17

TB

Question 18

Most common site of TB

Answer 18

Pulmonary TB 80%

Extrapulmonary:
Lymph node
GU
Bones and joints
Meninges
Intestine 
Skin

Question 19

Most common extrapulmonary site of TB

Answer 19

Lymph node

Question 20

Mycobacterium other than TB that affects lymph node

Answer 20

Mycobacterium scrofulaceum

Question 21

The progression to clinical disease in a previously unexposed immunocompetent person depends on 3 factors

Answer 21

Number of M tb inhaled

Question 22

Disease that develops in a previously uninfected person

Answer 22

Primary TB

Question 23

Inhaled bacilli implant in the distal air spaces of

Answer 23

lower part of upper lobe

Upper part of lower lobe

Question 24

1-1.5 cm area of grey white inflammation with consolidation develops that often

Macrophage
Lymphocyte
Multinucleated giant cells

Answer 24

caseates

caseous necrosis

Question 25

Bactermia with seeding of multiple sites result from

Answer 25

Natural Resistance Associated Macrophage Protein1 (NRAMP1) polymorphism

Question 26

after 3 weeks, activation of macrophage lead to formation of

Answer 26

Epitheloid granuloma hypersensitivity

Question 27

TST is a type of

Answer 27

Type IV Delayed hypersensitivity reaction

Question 28

Assay that detects MTBC and resistance to Rifampin

Answer 28

Xpert MTB/RIF

Question 29

Uses DNA strip that allows simultaneous molecular identification of TB and the most common genetic mutations causing resistance to Rifampicin and Isoniazid Provides result in 5 hours

Answer 29

Line Probe Assay

Question 30

Used for rapid identification of TB

Answer 30

Buffy coat

Question 31

Most common form of MTB

Answer 31

Pulmonary

Question 32

Responsible for caseous necrosis in TB

Answer 32

Phosphatides

Question 33

Classical tubercular lesion | Granuloma with typical epitheloid cells, lymphocytes fibrosis and

Answer 33

Langhan’s giant cells

Question 34

Provides a definitive diagnosis for active tuberculosis Used to monitor progress of patients while on treatment Confirm cure at the end of treatment

Answer 34

Direct Sputum Smear Microscopy

Question 35

Abnormalities often seen in xray

Answer 35

apicolordotic view

Question 36

Subpleural granuloma

Answer 36

Ghon’s focus

Question 37

Subpleural granuloma + associated LN

Answer 37

Ghon’s complex

Question 38

Usual site of primary TB

Answer 38

Middle to lower lobe

Question 39

Usual site of reactivation tuberculosis

Answer 39

Apex of the lungs

Question 40

Extrapulmonary TB

Answer 40

Renal Colon Spine

Question 41

TB of spine/bone

Answer 41

Pott’s

Question 42

Children most commonly affected vertebrae

Answer 42

Thoracic

Question 43

Adult most commonly affected vertebrae

Answer 43

Lower thoracic | Upper lumbar

Question 44

Present with skip lesions Cobble stone appearance Caseation

Answer 44

TB Colon

Question 45

Present with skip lesions Cobblestone apearance Noncaseating

Answer 45

Crohn’s

Question 46

``` Low grade fever Night sweats Weight loss Fatigue Cough and hemoptysis ```

Answer 46

TB

Question 47

TB cachexia is caused by

Answer 47

TNF alpha | Cachectin

Question 48

Delayed hypersensitivity Type IV skin test to assay Cel mediated immunity Read reaction 48-72 h Induration is considered + if 10 mm

Answer 48

PPD | Mantoux test

Question 49

PPD + reading for immunocompromised (HIV)

Answer 49

>5mm

Question 50

+ TST indicates

Answer 50

Exposure to organism | Does not indicate active disease