Thrombotic Agents

Question 1

What is fibrin and its role?

Answer 1

• insoluble protein
• key in clot formation

Question 2

What is thrombosis

Answer 2

Clot formation

Question 3

Which agents are used in the treatment and prevention of venous and arterial thrombi

Answer 3

• LMWH
• heparin
• DOAC
• warfarin

Question 4

Which agents are used in the treatment and prevention of arterial thrombi

Answer 4

• clopidogrel
• aspirin

Question 5

Which agent is used during MI for rapid dissolution of thromboembolism

Answer 5

Fibrinolytic agent - Streptokinase (1st gen)

Question 6

What do you know about thrombolytic/fibrinolytic agents? And give examples

Answer 6

• breaks down already formed clots
• removes fibrin
• aka plasminogen activators

Streptokinase
• 1st gen (old) - not selective

Alteplase
• 2nd (new) - selective

Question 7

What do you know about plasmin?

Answer 7

Breaks down clot

Question 8

Fibrinolytic - Indication

Answer 8

DVT
Arterial thromboembolism
Stroke
After MI

Question 9

Streptokinase and Alteplase MOA?

Answer 9

Activates plasminogen to dissolve already formed clot

Question 10

Which is first or third gen & selective or non selective

Answer 10

Stretokinase
• 1st gen
• non selective

Alteplase
• third
• selective