Calcium Channel Blockers

Question 1

CCB - MOA?

Answer 1

Block entry of Ca through L-type channels

Inhibits influx of ca through L-type channel, in vascular smooth muscle

Effects:
• reduced contractility
• reduced spread of electrical impulses
• vasodilation
• antiarythmic (only in non-dihydropyridine)

Question 2

CCB ADRs?

Answer 2

• constipation
• headache
• flushes
• peripheral odema
• tachycardia

Question 3

Which CCB has the longest half life?

Answer 3

Amplodipine

Question 4

Which cl