Drig Induced Blood Disorders

Question 1

What is drug induced agranulocytosis?

Answer 1

Decreased in neutrophil count

Question 2

Which gender is it more common in?

Answer 2

Female

Question 3

What are the symptoms?

Answer 3

• fever
• chills
• sore throat
• weakness

Question 4

Treatment

Answer 4

• remove offending agent
• anti microbial - for infection

Question 5

What is drug induced thrombocytopenia

Answer 5

Reduced blood platelet count - <150,000

Question 6

Symptoms

Answer 6

• bruising
• purple/red spots on skin
• nose bleeds

Question 7

Which drugs can cause thrombocytopenia?

Answer 7

• mythylodopa
• quinine
• furesimide

Question 8

Management?

Answer 8

• blood transfusion
• corticosteroids
• stop causative agents

Question 9

What is drug induced aplastic anemia

Answer 9

Bone marrow is unable to produce enough blood cells (RBC, WBC and platelets)

Question 10

Drugs act on which stem cells

Answer 10

Pluripotent stem cells

Question 11

Which other blood disorders does this cause?

Answer 11

• thrombocytopenia
• anemia
• neutropenia

Question 12

What is diagnosis criteria in blood cells counts?

Answer 12

2 of the following:
• WBC <3,500
• platelets <55,000
• hb <10g

Question 13

Management

Answer 13

• blood transfusion
• WBC or platelets transfusion
• bone marrow transplant
• remove causative drug

Question 14

What is immune haemolytic anemia?

Answer 14

Immune system attacks RBCs

Question 15

How to detect this?

Answer 15

Direct anti globulin test

Question 16

Which drugs cause high affinity antibodies

Answer 16

Penicillin

Question 17

Which drugs cause low affinity antibodies?

Answer 17

Quinidine

Question 18

Management

Answer 18

• Remove causative drug
• RBC transfusion

Question 19

What is G6PD hemolytic anemia

Answer 19

A lack of G6PD enzyme

Question 20

Symptoms?

Answer 20

• jaundice
• dark urine

Question 21

Non drug induced causes?

Answer 21

• infections
• diabetic ketoacidosis

Question 22

Which drugs can induce this?

Answer 22

• Nitrofurantoin
• sulfametgaxazole

Question 23

Management

Answer 23

• RBC transfusion
• remove causative drugs