Thrombosis Therapy and Side Effects

Question 1

Unfractionated Heparin

Answer 1

Tx: Prevention and treatment of venous thromboembolism

SE: HIT, osteoporosis (long-term), bleeding

Question 2

Dalteparin

Answer 2

Tx: Prevent thrombosis and embolism from clots

SE: Bleeding

Question 3

Enoxaparin

Answer 3

Tx: Drug of choice in pregnancy; prevention and treatment of venous thromboembolism

SE: HIT; osteoporosis and thrombocytopenia uncommon

Question 4

Tinzaparin

Answer 4

Tx: none listed

SE: HIT, osteoporosis and thrombocytopenia uncommon

Question 5

Fondaparinux

Answer 5

Tx: Given for HIT patients

SE: Bleeding

Note: no antidote

Question 6

Warfarin

Answer 6

Tx: Long-term coagulation

SE: Thrombosis (Protein C depression), bleeding.

Question 7

Lepirudin

Answer 7

–

Question 8

Bivalirudin

Answer 8

–

Question 9

Argatroban

Answer 9

–

Question 10

Dabigatran

Answer 10

–

Question 11

Rivaroxaban

Answer 11

–

Question 12

Apixaban

Answer 12

–

Question 13

Streptokinase

Answer 13

Tx: Acute MI, acute stroke, central DVT, multiple PE

Question 14

Urokinase

Answer 14

Tx: Acute MI, acute stroke, central DVT, multiple PE

Question 15

Reteplase

Answer 15

Tx: Acute MI, acute stroke, central DVT, multiple PE

Question 16

Tenecteplase

Answer 16

Tx: Acute MI, acute stroke, central DVT, multiple PE

Question 17

Aspirin

Answer 17

Often as “baby apsirin” to prevent and treat MI and stroke

Question 18

Dipyridamole

Answer 18

Tx: Weak anitplatelet effect

Question 19

Clopidogrel

Answer 19

Rx: –

SE: TTP (rare)

Question 20

Abciximab

Answer 20

Tx: –

SE: May elicit immune resposne

Question 21

Eptifibatide

Answer 21

–

Question 22

Tirofiban

Answer 22

–