Adrenergic MOA Flashcards
Receptors we’re about to deal with
- a1- vasoconstriction
- a2- Decreased sympathetic tone
- b1- Increase HR, force of contraction
- b2- Vasodilation, bronchodilation
- D1- Renal, Mesenteric, Cerebral arteriolodilation
Epinephrine
Nonselective Agonist: a1, a2, b1, b2
Norepinephrine
Nonselective Agonist: a1, a2, b1
Amphetamine
Indirect acting agonist; Increases release of NE
Isoproterenol
Nonselective Beta Agonist: b1, b2
Dobutamine
b1 Selective Agonist
Albuterol
b2 Selective Agonist
Terbutaline
b2 Selective Agonist
Phenylephrine
a1 Selective Agonist
Clonidine
a2 Selective Agonist
a-methyldopa
a2 Selective Agonist
Fenoldopam
D1 Selective Agonist
Dopamine
Mixed Acting Agonist: D1, a1, b1
Phentolamine
Nonselective Alpha Antagonist: a1, a2
Phenoxybenzamine
Nonselective Alpha Antagonist: a1, a2
Prazosin
a1 Selective Antagonist
Terazosin
a1 Selective Antagonist
Propranolol
Nonselective Beta Antagonist (1st gen): b1, b2
Timolol
Nonselective Beta Antagonist (1st gen): b1, b2
Metoprolol
b1 selective Antagonist (2nd gen)
Atenolol
b1 selective Antagonist (2nd gen)
Bisoprolol
b1 selective Antagonist (2nd gen)
Carvedilol
Nonselective Beta Antagonist (3rd gen “A”): b1, b2
Labetalol
Nonselective Beta Antagonist (3rd gen “A”): b1, b2
Betaxolol
b1 Selective Antagonist (3rd gen “B”)
Tyramine
Indirect Agonist: Increases cytoplasmic NE. Prevents NE re-uptake
Guanethidine
Flase neurotransmitter
Reserpine
Release of empty vesicles (?)
a-me-tyrosine
Inhibits tyrosine hydroxylase
Ephedrine
Mixed, direct b2/indirect agonist (??)
