RA & Gout - Therapy & Side Effects

Question 1

Abatacept

Answer 1

RA that is refractory to MTX or TNF-alpha inhibitors

headaches; infections

Question 2

Rituximab

Answer 2

RA that is refractory to MTX or TNF-alpha inhibitors

infections, hypersensitivity

Question 3

Certolizumab

Answer 3

RA

infections

Question 4

Golimumab

Answer 4

RA

infections

Question 5

Etanercept

Answer 5

RA

Question 6

Infliximab

Answer 6

RA

antigenic response to murine monoclonal Ab

Question 7

Adalimumab

Answer 7

RA

fully human, so no antigenic response

Question 8

Anakinra

Answer 8

RA

Question 9

Toclizumab

Answer 9

RA

Question 10

Indomethacin

Answer 10

RA; acute gouty arthritis

gastric & duodenal ulcers

Question 11

Naproxen

Answer 11

RA; acute gouty arthritis

gastric & duodenal ulcers

Question 12

COX-2 inhibitors

Answer 12

RA

less ulceration than Indomethacin & Naproxen

Question 13

Febuxostat

Answer 13

chronic tophaceous gout

nausea, rash, arthralgias

Question 14

Allopurinol

Answer 14

chronic tophaceous gout

acute attacks of gouty arthritis during early part of treatment

Question 15

Colchicine

Answer 15

acute gouty arthritis

peripheral neuropathy and neutropenia with long-term use

Question 16

Glucocorticoids

Answer 16

RA; acute gouty arthritis

Cushingoid symptoms

Question 17

Quinolones

Answer 17

RA, SLE

retinal damage

Question 18

Gold Salts

Answer 18

RA

“serious side effects” - Pharm drug table

Question 19

Sulfasalazine

Answer 19

RA (quick acting)

nausea/vomiting; skin rash, neutropenia

Question 20

Methotrexate

Answer 20

RA (gold standard) (takes several weeks to start working)

nausea, stomatitis, hepatotoxicity

Question 21

Leflunomide

Answer 21

RA (takes several weeks to start working)

diarrhea, hepatotoxicity

Question 22

Pegloticase

Answer 22

chronic tophaceous gout

Question 23

Probenecid

Answer 23

chronic tophaceous gout

acute gouty arthritis