Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology, Unit 2 > Malaria - Classes & MOA > Flashcards

Malaria - Classes & MOA Flashcards

1
Q

Lumefantrine

Class?

A

Aminoalcohol

no mechanism listed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Chloroguanide

Class? Mechanism?

A

Class: Anti-Folate

Mechanism: DHFR inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Atovaquone

Class? Mechanism?

A

Class: Napthalene

Mechanism
-depolarize parasite mitochondria and inhibit electron transport

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Tetracycline

Class?

A

Class: Anti-biotic

no mechanism listed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Pyrimethamine

Class? Mechanism?

A

Class: Anti-Folate

Mechanism: DHFR inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Hydroxychloroquine

Class? Mechanism?

A

Class: Quinolone derivative

Mechanism: accumulate in parasite’s food vacuole; disrupt heme polymerization to hemozoin, causing oxidative damage to membranes and digestive proteases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Clindamycin

Class?

A

Class: Anti-biotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Chloroquine

Class? Mechanism?

A

Class: Quinolone derivative

Mechanism: accumulate in parasite’s food vacuole; disrupt heme polymerization to hemozoin, causing oxidative damage to membranes and digestive proteases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Amantadine

Mechanism?

A

no class listed

Mechanism: positive charge helps chloroquine overcome chloroquine-resistant malaria vacuoles; point mutations against Amantidine will return bacteria to Chloroquine-sensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Quinine

Class? Mechanism?

A

Class: Quinolone derivative

Mechanism: accumulate in parasite’s food vacuole; disrupt heme polymerization to hemozoin, causing oxidative damage to membranes and digestive proteases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Artesunate

Class? Mechanism?

A

Class: Artemisinin compound

Mechanism: selectively inhibit P. falciprum SERCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Mefloquine

Class? Mechanism?

A

Class: Quinolone derivative

Mechanism: accumulate in parasite’s food vacuole; disrupt heme polymerization to hemozoin, causing oxidative damage to membranes and digestive proteases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Artemether

Class? Mechanism?

A

Class: Artemisinin compound

Mechanism: selectively inhibit P. falciprum SERCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Primaquine

Class? Mechanism?

A

Class: Quinolone derivative

Mechanism: forms quinone-quinolone intermediates that oxidize schizont membranes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Doxycycline

Class?

A

Class: anti-biotic

no mechanism listed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly

Pharmacology, Unit 2 (22 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions