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Pharmacology, Unit 2 > RA & Gout - MOA > Flashcards

RA & Gout - MOA Flashcards

1
Q

Abatacept

A

inhibit T cell activation; induce T cell apoptosis

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2
Q

Certolizumab

A

block binding of TNF to TNF-receptor

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3
Q

Rituximab

A

anti-CD20 monoclonal Ab, decreases circulating B cells

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4
Q

Golimumab

A

block binding of TNF to TNF-receptor

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5
Q

Anakinra

A

IL-1 receptor antagonist

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6
Q

Etanercept

A

block binding of TNF to TNF-receptor

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7
Q

Tocilizumab

A

IL-6 receptor antagonist

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8
Q

Infliximab

A

block binding of TNF to TNF-receptor

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9
Q

Indomethacin

A

eliminates pain and inflammation; no effect on disease progression

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10
Q

Adalimumab

A

block binding of TNF to TNF-receptor

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11
Q

Naproxen

A

eliminates pain and inflammation; no effect on disease progression

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12
Q

COX-2 inhibitors

A

eliminates pain and inflammation; no effect on disease progression

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13
Q

Febuxostat

A

Xanthine Oxidase antagonist

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14
Q

Allopurinol

A
  1. decrease UA synthesis by competitively inhibiting XO

2. its metabolite, Alloxanthine, is a non-competitive inhibitor of XO

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15
Q

Colchicine

A

prevent tubulin polymerization, leading to inhibition of leukocyte migration, phagocytosis, and cytokine release

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16
Q

Glucocorticoids

A
  1. inhibit PLA2 and function of prostaglandins

2. inhibit cytokine production and prevent COX-2 induction

17
Q

Quinolones

A

reduce T cell activation and chemotaxis

18
Q

Gold Salts

A

anti-pruritic; repress immune responsiveness by inhibiting functional capacity of macrophages

19
Q

Sulfasalazine

A

inhibit release of IL-1, TNF-alpha

20
Q

Methotrexate

A
  1. inhibit AICAR transformylase and thymidylate synthetase, with effects on PMN chemotaxis
  2. cause increased adenosine to inhibit inflammataion
21
Q

Leflunomide

A

inhibit DHODH to inhibit T-lymphocyte response

22
Q

Pegloticase

A

convert UA to allantoin

23
Q

Probenecid

A

compete with urate at the anionic transport site of renal tubule, thus inhibiting urate reabsorption

Pharmacology, Unit 2 (22 decks)

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