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Pharmacology, Unit 2 > Thrombosis Class & MOA > Flashcards

Thrombosis Class & MOA Flashcards

1
Q

Unfractionated Heparin

A

Indirect Thrombin Inhibitor

Binds antithrombin, potentiating formation of antithrombin-coagulation factor complex (Xa, IIa)

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2
Q

Dalteparin

A

Indirect Thrombin Inhibitor

LMWH that inhibits thrombin less effectively than Xa

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3
Q

Enoxaparin

A

Indirect Thrombin Inhibitor

LMWH that inhibits thrombin less effectively than Xa

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4
Q

Tinzaparin

A

Indirect Thrombin Inhibitor

LMWH that inhibits thrombin less effectively than Xa

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5
Q

Fondaparinux

A

Indirect Thrombin Inhibitor

Synthetic polysaccharide that binds active site of antithrombin; inhibits Xa.

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6
Q

Warfarin

A

Vit. K antagonist

Blocks actions of Vit K-dependent gamma carboxylation of Factors II, VII, IX, X, Protein C and S. It does not affect factors already produced.

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7
Q

Lepirudin

A

Direct Thrombin Inhibitor

Inactivates fibrinogen-bound AND unbound thrombin; irreversible

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8
Q

Bivalirudin

A

Direct Thrombin Inhibitor

Inactivates fibrinogen-bound AND unbound thrombin; irreversible

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9
Q

Argatroban

A

Direct Thrombin Inhibitor

Inactivates fibrinogen-bound AND unbound thrombin.

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10
Q

Dabigatran

A

Direct Thrombin Inhibitor

Inactivates fibrinogen-bound AND unbound thrombin; competitive (reversible!).

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11
Q

Rivaroxaban

A

Direct Xa Inhibitor

Reversible, binds active site of Xa

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12
Q

Apixaban

A

Direct Xa Inhibitor

Reversible, binds active site of Xa

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13
Q

Streptokinase

A

Fibrinolytic

Lyses already formed clots by activating circulating plasminogen (not clot specific).

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14
Q

Urokinase

A

Fibrinolytic

Lyses already formed clots by activating circulating plasminogen

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15
Q

Reteplase

A

Fibrinolytic

Lyses already formed clots; more clot specific, less systemic activation

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16
Q

Tenecteplase

A

Fibrinolytic

Lyses already formed clots; more clot specific, less systemic activation.

17
Q

Aspirin

A

Antiplatelet

Irreversibly inhibits platelets, preventing thromboxane A2 formation

18
Q

Dipyridamole

A

Antiplatelet

PDE inhibitor –> increase in platelet cAMP

19
Q

Clopidogrel

A

Antiplatelet

Inhibits platelet ADP receptors

20
Q

Abciximab

A

Antiplatelet

Monoclonal antibody against GPIIb/IIIa

21
Q

Eptifibatide

A

Antiplatelet

Fibrinogen Analog which competes with endogenous fibrinogen for IIa/IIIb

22
Q

Tirofiban

A

Antiplatelet

Fibrinogen analogs which compete with endogenous fibrinogen and vWF for IIa/IIIb.

Pharmacology, Unit 2 (22 decks)

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