things i might review for final

Question 1

dysplasia

Answer 1

loss of normal tissue architectur

Question 2

what drug or class ig recruits t cells to kill b cells?

Answer 2

blinatumomab (bite?)

Question 3

HER2 drug

Answer 3

tucatinib

Question 4

EGFR mutation positive drug

Answer 4

afatinib (egfr=growth=fat people)

Question 5

androstenedione to estrone enzyme

Answer 5

aromatase

Question 6

vincristine class and cell cycle checkpoint target

Answer 6

vinca alkaloid
G2/M

Question 7

know which classes do and do not cause dna damage

Answer 7

ok will do, the answer for which didnt was paclitaxel in the review tho

Question 8

doxorubicin combined with what drug to alleviate toxic SE

Answer 8

dexrazoxane

Question 9

class that can cause secondary malignancies

Answer 9

alkylators and platinum compounds so this is all of the C ones like chlorambucil, cyclophos, mitomycin C, cisplatin

Question 10

leucovorin is used in combo with what drug and why

Answer 10

5-FU, increases efficacy of drug

Question 11

mesna used with what drug and why

Answer 11

cyclophos for hemorrhagic cystitis

Question 12

development of drug resistance to many chemo drugs is likely caused by?

Answer 12

increased cellular efflux of drugs

Question 13

carcinoma = tumor derived from ________ cells

Answer 13

epithelial

Question 14

what is Cobas test?

Answer 14

determining sequence of EGFR gene to help with diagnosis

Question 15

cell cycle checkpoint targeted by palbociclib (CDK4/6 inhibitor)

Answer 15

G1 because cyclin binds to CDK to get into next phas

Question 16

tumor suppressor
BRCA or HER2

Answer 16

BRCA

Question 17

hormone produced in anterior pituitary gland

Answer 17

LH

Question 18

estrogen receptor bind estrogen where in the cell

Answer 18

cytoplasm

Question 19

CYP19 is also called

Answer 19

aromatase

Question 20

drug that inhibits estrogen throughout entire body

Answer 20

fulvestrant

Question 21

What is unique about the action of tamoxifen as compared to fulvestrant?
A. Leads to ER degradation
B. Holds ER out of nucleus
C. Ejects ER from cell
D. Activates ER in bone

Answer 21

D

Question 22

Which of the following is NOT a hormone responsive cancer type?
A. Breast cancer
B. Ovarian cancer
C. Prostate cancer
D. Endometrial cancer

Answer 22

B somehow

Question 23

drug that acts DIRECTLY on AR

Answer 23

enzalutamide or other -lutamide

Question 24

3 AA’s that are targets of phosphorylation

Answer 24

tyrosine
serine
threonine
(all have -OH)

Question 25

EGFR inhibitor drugs

Answer 25

GOAL
and all end in -tinib

Question 26

what mutation in EGFR confers resistance to some of the inhibitors

Answer 26

t790m

Question 27

philadelphia drug

Answer 27

imatinib

Question 28

Which type of kinase inhibitor can bind in the ATP binding site and stabilize the inactive conformation of a kinase?
Type I
Type II
Type III
Type IV

Answer 28

type II, review these on your own too

Question 29

antifolates induce what cell cycle checkpoint

Answer 29

S

Question 30

5-FU OD rescue

Answer 30

thymidine

Question 31

alkylating agents are potent ?

Answer 31

electrophiles

Question 32

crosslinkers = what classes

Answer 32

alkylating and platinum

Question 33

topo inhibitors what phase of cell cycle

Answer 33

S

Question 34

block polymerization of tubulin

Answer 34

vincristine and eribulin

Question 35

“u” before mab means?

Answer 35

fully humanized

Question 36

CTLA-4 drug

Answer 36

ipilimumab

Question 37

cancer biomarker test protein for pembro

Answer 37

PDL1 NOT pd1

Question 38

drug that exerts antitumor effects by inhibiting interaction BETWEEN PD1 and PDL1

Answer 38

atezolizumab