things i might review for final Flashcards

this is just stuff i didn't recognize at first glance

1
Q

dysplasia

A

loss of normal tissue architectur

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2
Q

what drug or class ig recruits t cells to kill b cells?

A

blinatumomab (bite?)

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3
Q

HER2 drug

A

tucatinib

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4
Q

EGFR mutation positive drug

A

afatinib (egfr=growth=fat people)

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5
Q

androstenedione to estrone enzyme

A

aromatase

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6
Q

vincristine class and cell cycle checkpoint target

A

vinca alkaloid
G2/M

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7
Q

know which classes do and do not cause dna damage

A

ok will do, the answer for which didnt was paclitaxel in the review tho

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8
Q

doxorubicin combined with what drug to alleviate toxic SE

A

dexrazoxane

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9
Q

class that can cause secondary malignancies

A

alkylators and platinum compounds so this is all of the C ones like chlorambucil, cyclophos, mitomycin C, cisplatin

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10
Q

leucovorin is used in combo with what drug and why

A

5-FU, increases efficacy of drug

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11
Q

mesna used with what drug and why

A

cyclophos for hemorrhagic cystitis

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12
Q

development of drug resistance to many chemo drugs is likely caused by?

A

increased cellular efflux of drugs

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13
Q

carcinoma = tumor derived from ________ cells

A

epithelial

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14
Q

what is Cobas test?

A

determining sequence of EGFR gene to help with diagnosis

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15
Q

cell cycle checkpoint targeted by palbociclib (CDK4/6 inhibitor)

A

G1 because cyclin binds to CDK to get into next phas

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16
Q

tumor suppressor
BRCA or HER2

17
Q

hormone produced in anterior pituitary gland

18
Q

estrogen receptor bind estrogen where in the cell

19
Q

CYP19 is also called

20
Q

drug that inhibits estrogen throughout entire body

A

fulvestrant

21
Q

What is unique about the action of tamoxifen as compared to fulvestrant?
A. Leads to ER degradation
B. Holds ER out of nucleus
C. Ejects ER from cell
D. Activates ER in bone

22
Q

Which of the following is NOT a hormone responsive cancer type?
A. Breast cancer
B. Ovarian cancer
C. Prostate cancer
D. Endometrial cancer

23
Q

drug that acts DIRECTLY on AR

A

enzalutamide or other -lutamide

24
Q

3 AA’s that are targets of phosphorylation

A

tyrosine
serine
threonine
(all have -OH)

25
EGFR inhibitor drugs
GOAL and all end in -tinib
26
what mutation in EGFR confers resistance to some of the inhibitors
t790m
27
philadelphia drug
imatinib
28
Which type of kinase inhibitor can bind in the ATP binding site and stabilize the inactive conformation of a kinase? Type I Type II Type III Type IV
type II, review these on your own too
29
antifolates induce what cell cycle checkpoint
S
30
5-FU OD rescue
thymidine
31
alkylating agents are potent ?
electrophiles
32
crosslinkers = what classes
alkylating and platinum
33
topo inhibitors what phase of cell cycle
S
34
block polymerization of tubulin
vincristine and eribulin
35
"u" before mab means?
fully humanized
36
CTLA-4 drug
ipilimumab
37
cancer biomarker test protein for pembro
PDL1 NOT pd1
38
drug that exerts antitumor effects by inhibiting interaction BETWEEN PD1 and PDL1
atezolizumab
39