L immunology oncology Flashcards
Antibody producing cells:
A. T cells
B. NK cells
C. B cells
D. Gay cells
C. B cells
Fully human
A. -o
B. -xi
C. -zu
D. -u
D
Humanized
A. -o
B. -xi
C. -zu
D. -u
C
Mouse
A. -o
B. -xi
C. -zu
D. -u
A
Chimeric
A. -o
B. -xi
C. -zu
D. -u
B
T or F:
HER2 is genomically amplified in breast cancer
True
Trastuzumab more commonly known name
herceptin
Trastuzumab is a recombinant _________ mab specific for ____
humanized
HER2
Trastuzumab binds to receptor and induces antibody-dependent cellular _______
cytotoxicity
primary indication of trastuzumab
breast cancers that overexpress HER2
4 toxicities listed under trastuzumab
flu like sxs
risk of cardiomyopathy/CHF
increase in myelosuppression
hypersensitivity rxs
Pertuzumab binds to her2 and inhibits ______***
dimerization (which also inhibits kinase activity)
T or F:
Pertuzumab and Trastuzumab are used in combination
True
what was the significance of the CLEOPATRA trial?
using both antibodies (pertuz and trastuz) against HER2 increased efficacy
what does margetuximab target
HER2
Cetuximab class
EGFR antibody
Cetuximab binds specifically to what
extracellular domain of the EGF receptor
T or F:
Cetuximab is a competitive inhibitor
true
Cetuximab competitively inhibits binding of ____ and ____
EGF
TGF-alpha
T or F:
Cetuximab blocks phosphorylation and activation of receptor-associated kinases **
true
primary indication of Cetuximab
tx of colorectal and head and neck cancers
big all caps thing under toxicities for cetuximab
severe infusion reaction in ~3% of patients - usually first dose if that matters
T or F:
Panitumumab is fully humanized
true
where does panitumumab bind?
extracellular domain of the EGF receptor
primary indication of panitumumab
tx of colorectal cancer
T or F:
Panitumumab carries the same infusion toxicities as cetuximab
false, it dont
Bevacizumab is specific for ?
VEGF
What is the significance of Bevacizumab binding VEGF?
It blocks endothelial cell proliferation and new blood vessel formation
T or F:
There is no evidence of efficacy of Bevacizumab as a single agent
true
Bevacizumab is used in combo with ______ based chemotherapy for 1st line tx of metastatic colorectal cancer
5-FU
Binds VEGF:
A. Bevacizumab
B. Ramucirumab
A
binds VEGFR
A. Bevacizumab
B. Ramucirumab
B
Which of the following antibodies targets Her2?
A. Neratinib
B. Cetuximab
C. Lapatinib
D. Pertuzumab
D
What was the first immunotherapy?
A. Pertuzumab
B. Keytruda
C. Coley’s toxin
D. Trastuzumab
my toxin
The antibody Fakeumab has just entered the market. What type of the antibody was it?
A. Fully human
B. Humanized
C. Fully mouse
D. Chimeric
a
T or F:
CD20 works with B-cell receptor to drive proliferation of B-cells
true
T or F:
CD20 plays a role in the proliferation of B-cell lymphomas
true
Rituximab is a _____ antibody
CD20
what does rituximab bind to?
CD20
Ofatumumab is a ________ antibody specific for _____ originally developed to treat multiple sclerosis and now used in CLL
fully human monoclonal
CD20
Rituximab and Obinutuzumab are currently approved for what?
B-cell lymphomas (non-hodgkins lymphoma) that target different binding sites on CD20
Daratumumab target
CD38
Multiple myeloma is a cancer of __________ plasma cells
malignant
CD38 is found on ______ cells that do not have _____ on their surface
plasma
CD20
T or F:
Daratumumab also eliminates NK cells
true
antibody drug-conjugates both have which drug involved
trastuzumab
Trastuzumab Emtansine (TDM1) binds to what? What does this lead to?
HER2/Neu receptor
usual herceptin response
T or F:
Emtansine is a cytotoxic agent
true
Emtansine enters cells and _______ microtubule assembly
inhibits
trastuzumab emtansine is approved for what
as a 2nd line tx for HER2-positive metastatic breast cancer
3 toxicities listed under trastuzumab emtansine
- adverse effects of trastuzumab
- thrombocytopenia (mertansine)
- Hepatotoxicity (mertansine)
Another ADC is trastuzumab-deruxtecan. what class is deruxtecan?
TOPO I inhibitor
negative selection of T-cells that bind to “self” peptides in the thymus:
A. central tolerance
B. peripheral tolerance
A central
self reactive t cells that escape the thymus and are inactivated to an unresponsive state by Tregs or fail to be properly stimulated by APCs
A. central tolerance
B. peripheral tolerance
B
where is central t-cell tolerance occuring?
thymus
taking a break here
