E4 Lupus Flashcards
jesus christ
3 main etiologies of lupus
genetics, hormonal, environment
T or F:
2nd degree relatives w/ lupus equates to 20 times more likely to develop it
false, 1st degree (dumb card im sorry)
hormonal etiology:
_______ production may modulate the incidence and severity SLE
estrogen
weird environmental factor contributing to lupus etiology
UV light, so sunscreen is imporTENT (also pesticides but she didnt talk about that as much)
DILE acronym for lupus
My
Pretty
Malar
Probably
Has
A
TransIent (capital I too)
Quality
drugs for that acronym for DILE
Methimazole
Propylthiouracil
Methyldopa
Minocycline
Procainamide
Hydralazine
Anti-TNF agents (infliximab and etanercept)
Terbinafine
Isoniazid
Quinidine
Which medication is most likely contributing to KB’s lupus-like syndromes?
Tylenol
Sprintec
Sertraline
Minocycline
minocycline
what is malar?
butterfly rash thing, resembles the wings, typically on face and shit i think
2 musculoskeletal s/sxs
arthralgias and myalgias
mucocutaneous s/sxs (5)
butterfly rash
photosensitivity
ulcers
discoid rash
raynauds pheno
1 ophthalmologic sx of lupus
lupus retinopathy (is this different than other retinopathies lol)
1 renal sx lupus
lupus nephritis*
3 pulmonary sxs lupus
dyspnea
pleuritis
pleural effusion
thrombosis sx lupus
antiphospholipid antibodies (say that 5 times fast)
immunologic sx lupus
autoantibodies
What is a classic skin manifestation of lupus?
A. Butterfly-shaped rash on the face
B. Blisters on the hand
C. Scaling on the scalp
D. Darkening around the eyes
A
Which of the following is a common trigger for lupus flare-ups?
A. Regular exercise
B. High sodium intake
C. Sun exposure
D. High cholesterol
C
2 very important diagnostic tools for lupus
SLICC
EULAR/ACR
SLICC:
Must meet ≥ __ total features with 1 from each group
OR?
4
or biopsy proving lupus nephritis (ANA+ and Anti-dsDNA+)
EULAR/ACR:
Patient’s score is ≥ __ AND at least 1 clinical criterion is fulfilled
10
T or F:
EULAR/ACR
Only the highest-weighted criterion score within a single domain is used
true
4 “very important” key labs for lupus
- Anti-Nuclear Antibody (ANA)
- Anti-double-stranded DNA (Anti-dsDNA)
- Anti-Smith Antibody (Anti-SM)
- Antiphospholipid antibody
not specific for diagnosis:
A. ANA
B. Anti-dsDNA
C. Anti-SM
D. Antiphospholipid antibody
A
High specificity for diagnosis of lupus
A. ANA
B. Anti-dsDNA
C. Anti-SM
D. Antiphospholipid antibody
B and C