E2 Supp Care I Flashcards
what are the 5 types of N/V?
Anticipatory
Acute
Delayed
Breakthrough
Refractory
Type of N/V that is considered a “learned response” and has had hypnosis be successful (lol)
Anticipatory
Type of N/V that usually occurs within 24 hours of receiving chemo
acute
type of N/V occuring >24 hours after chemo
delayed
type of N/V that occurs even if on scheduled anti-emetics prior to chemo
Breakthrough
Type of N/V that persists after failing other therapies
refractory
what does the chemo trigger zone (CTC) stimulate?
the vomiting center (located in nucleus tractus solitarii)
Nausea -> followed by _________ -> finally emesis
wretching
what is wretching
labored movement of abdominal and thoracic muscles before puking
5 neurotransmitters implicated in CINV
dopamine
histamine
ach
serotonin
substance p
she said the last two were the important ones for us tho
T or F
Level 1 and 2 agents do not contribute to the emetogenicity of the regimen
True
T or F:
younger patients are a bigger risk factor for CINV than old asses
true somehow
what can be protective for CINV?
chronic ethanol loll
what is prophylaxis for acute N/V based on?
emetogenic potential of chemotherapy
How many different drug classes do we use when pt is classified as highly emetogenic (regimen A). what are they?
- NK-1 antagonist
Steroid
5-HT3 antagonist
Atypical Antipsychotics
what do the NK-1 antagonists end with?
-repitant
what is the steroid used for emetogenic pts
dexamethasone
what 2 classes do we ALWAYS use in emetogenic regimens? (unsure if this is specifically highly or not at the time of making this card)
5-HT3 antag and steroid
what do the 5-HT3 antags end with>
-setron
what atypical antipsychotic do we use for emetogenic shit
olanzapine
what random ass drug can be added on to highly emetogenic regimen B and C?
lorazepam
what is the moderately emetogenic regimen A? (classes)
steroid and 5-HT3 antag
what is the moderately emetogenic regimen B? (classes)
5-HT3 antag and a steroid
what is the moderately emetogenic regimen C? (classes)
NK-1 antag
steroid
5-HT3 antag
T or F
Low emetogenic regimens require choosing both drug class options
false, only one needed between steroid and 5-HT3 antag
name some of the classes included in breakthrough N/V regimen (theres a lot)
dopamine receptor antag
phenothiazines
antipsychotic
benzo
cannabinoid
serotonin agonist
steroids
anticholinergics
delayed N/V typically involves use of one of the following:
________
________
________
dexamethasone
NK-1 antag
Olanzapine
4 actions for anticipatory NV
prevention
behavioral
acupuncture
lorazepam
prevention guidelines for high to moderate emetogenic risk with oral chemo
5-Ht3 antag before chemo and continue daily
prevention guidelines for low to minimal emetogenic risk with oral chemo (3)
metoclopramide
prochlorperazine
5-HT3 antag
prevention guidelines for radiation induced emesis
5-HT3 antag po with or without dexa
are the common toxicities across classes that important for us to know?
please someone let me know
T or F:
emetogenicity is additive
true, adding two agents can make it worse