E2 Colorectal Cancer Flashcards
all of the risk factors for this one are self explanatory so im not typing them
maybe just recognize crohns and colitis and FAP (not that fap)
T or F:
>95% of colorectal cancers are adenocarcinomas
true
2 testing-work up options
microsatellite instability (MSI)
and
DNA mismatch repair (DNA MMR) (testing for loss of genes involved with that)
T or F:
pts with stage II disease have increased benefit from adjuvant 5-FU compared to stage III
false, stage III benefits from 5-FU, stage 2 does not
T or F:
chemo is the gold standard in stage II colon cancer and above
false, dont do it in stage II
T or F:
radiation therapy is well established for rectal cancer and not colon cancer
true
what stages of colorectal cancer are potentially curable
stage I, II, III
T or F:
surgery alone is definitive therapy in stages I and II
true
what is FOLFOX
5-FU
leucovorin
Oxaliplatin
what is CapeOX
capecitabine
oxaliplatin
what is in FOLFIRI
5-FU
leucovorin
irinotecan (theres I’s in folfiri) and it ends with iri
T or F:
Capecitabine is = to bolus 5-FU and leucovorin in stage III
true
T or F:
Bevacizumab, cetuximab, panitumumab, and irinotecan play a major role in stage III
false, they do not play a role at all
what stages do you use FOLFOX or FOLFIRI
stage II
T or F:
FOLFOX has more toxicities due to oxaliplatin
true (paresthesia and neutropenia) + GI oops
NCCN preferred regimens in low risk
capeox 3 months
folfox 3-6 months
NCCN preferred regimens in high risk
capeox 3-6 months
FOLFOX 6 months
requires port for administration
A. FOLFOX
B. CapeOX
A
hand foot syndrome
A. FOLFOX
B. CapeOX
B
which drug used in capeox requires renal dose adjustments *
capecitabine
T or F:
capecitabine is IV bolus administered
false, oral
what 3 things listed on slide 39 determine which chemo regimen to use?
neuropathy
UGT1A1 deficiency (irinotecan)
1 vs 2 vs 3 drugs (?)
T or F:
pembro and nivolumab show benefit in the metastatic setting
true
T or F:
pembro and nivolumab are approved for patients before FOLFOX and FOLFIRI
false, after