Thiamine

Question 1

Thiamine

Class

Answer 1

• Vitamin B-1

Question 2

Thiamine

MOA

Answer 2

• Combines with ATP to form thiamine pyrophosphate coenzyme, a necessary component for carbohydrate metabolism
• The brain is extremely sensitive to thiamine deficiency

Question 3

Thiamine

Indications

Answer 3

• Coma of unknown origin
• Delirium tremens
• Beriberi
• Wernicke’s encephalopathy

Question 4

Thiamine

Contraindications

Answer 4

• None

Question 5

Thiamine

Adverse reactions

Answer 5

• Hypotension from too fast or too much
• Anxiety
• Diaphoresis
• N/V
• Allergies are very rare

Question 6

Thiamine

Drug Interactions

Answer 6

• Give thiamine before glucose under all circumstances

Question 7

Thiamine

Dosage

Answer 7

• Adult:
  
  • 100 mg slow IV or IM
• Ped:
  
  • 10-25 mg slow IV or IM

Question 8

Thiamine

Duration

Answer 8

• Onset: Rapid
• Peak: Varies
• Duration: Dependent on degree of deficiency

Question 9

Thiamine

Special Considerations

Answer 9

• Pregnancy Cat: A
• Large IV doses may cause respiratory difficulty
• Anaphylaxis reactions reported