Fentanyl (Sublimase)

Question 1

Fentanyl

Class

Answer 1

• Narcotic Analgesic (schedule II)

Question 2

Fentanyl

Mechanism of Action

Answer 2

• Opioid receptor agonist
• Increases tone and decreases smooth muscles of the GI tract

Question 3

Fentanyl

Indications

Answer 3

• Treat moderate to severe pain
• Anesthetic for procecural sedation

Question 4

Fentanyl

Contraindications

Answer 4

• Myasthenia gravis
  
  • autoimmune neuromuscular disease
• Children under 2 yo

Question 5

Fentanyl

Adverse reactions

Answer 5

• Skeletal and thoracic muscular rigidity
• Bradycardia
• SZ
• Diaphoresis

Question 6

Fentanyl

Drug interactions

Answer 6

• Alcohol and CNS depressants

Question 7

Fentanyl

Dosage and administration

Answer 7

• Adult:
  
  • 25-100mcg (0.5-2mcg/kg) IM, IV, IN
• Ped:
  
  • 2-12 yo get 1.7-3.3mcg/kg IM, IV

Question 8

Fentanyl

Duration of action

Answer 8

• Onset
  
  • IV immediate
  • IM 7-15 min
• Peak effect
  
  • IV 3-5 min
  • IM 30 min
• Duration
  
  • IV 30-60 min
  • IM 1-2hrs

Question 9

Fentanyl

Special considerations

Answer 9

• Pregnancy: Cat C
• May cause severe hypoventilation
• Narcan as antidote