Dopamine Flashcards

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1
Q

Dopamine

Class

A
  • Sympathomimetic
  • Inotropic agent
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2
Q

Dopamine

MOA

A
  • Immediate metabolic precursor to norepi
  • Increases systemic vascular resistance
  • Dilates renal and splanchnic vasculature
  • Increases myocardial contractility and stroke volume
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3
Q

Dopamine

Indications

A
  • Cardiogenic shock
  • Septic shock
  • Spinal shock
  • Hypotension with low cardiac output states
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4
Q

Dopamine

Contraindications

A
  • VF
  • Tachyarrhythmias
  • Hypovolemic shock
  • Phechromocytoma (tumor of adrenal glands)
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5
Q

Dopamine

Adverse reactions

A
  • Cardiac arrhythmias
  • HTN
  • Increased myocardial O2 demand
  • Extravasation may cause tissue necrosis
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6
Q

Dopamine

Drug interactions

A
  • Incompatible in alkaline solutions
  • MAOIs enhance effects
  • Bretylium may potentiate effect (antiarrythmic)
  • Beta-blockers may antagonize effects
  • When administered with phenytoin (sz) may cause:
    • hypotension
    • bradycardia
    • sz
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7
Q

Dopamine

Dosage

A
  • Adult & Ped: 2-20 µg/kg/min, titrate for effect
  • Dopaminergic response: (dilates vessels in kidneys; increased urine output): 2-4µg/kg/min
  • Beta-adrenergic response: (positive chronotropic & inotropic): 4-10µg/kg/min
  • **Alpha stimulant/vasoconstict: **10-20µg/kg/min
  • Reverse renal effects/override alpha effects: > 20 µg/kg/min
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8
Q

Dopamine

Duration of action

A
  • Onset: 1-4 min
  • Peak: 5-10 min
  • Duration: effects cease almost immediately after infusion is shut off
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9
Q

Dopamine

Special considerations

A
  • Preg Cat: C
  • Effects are dose dependant
  • Avoid extravasation
  • Always monitor drip rate
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