Solu-Medrol Flashcards

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1
Q

Methylprednisolone Sodium Succinate (Solu-Medrol)

Class

A
  • Anti-inflammatory glucocorticoid (steroid)
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2
Q

Methylprednisolone Sodium Succinate (Solu-Medrol)

Mechanism of action

A
  • Synthetic corticosteroid that suppresses acute and chronic inflammation (treats edema)
  • Potentiates vascular smooth muscle relaxation by beta adrenergic agonists
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3
Q

Methylprednisolone Sodium Succinate (Solu-Medrol)

Indications

A
  • Acute spinal cord trauma
  • Anaphylaxis
  • Bronchodilator for unresponsive asthma
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4
Q

Methylprednisolone Sodium Succinate (Solu-Medrol)

Contraindications

A
  • Premature infants
  • Systemic fungal infections
  • Use cautiosuly for pt with GI bleeding, sepsis, local infection
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5
Q

Methylprednisolone Sodium Succinate (Solu-Medrol)

Adverse reactions

A
  • HA
  • N/V
  • HTN
  • Sodium water retention
  • CHF
  • Hypokalemia
  • Alkalosis
  • Peptic ulcer disease
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6
Q

Methylprednisolone Sodium Succinate (Solu-Medrol)

Drug interactions

A
  • Hypoglycemic response to insulin and hypoglycemic agents may be blunted
  • May increase hypokalemia
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7
Q

Methylprednisolone Sodium Succinate (Solu-Medrol)

Dosage and administration

A

Adult & Ped:

  • Acute spinal cord injury:
    • 30 mg/kg IV over 30 minutes
      • Followed by infusion: 5.4 mg/kg/h
  • Asthma/COPD:
    • 1-2 mg/kg IV
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8
Q

Methylprednisolone Sodium Succinate (Solu-Medrol)

Duration of action

A
  • Onset of action: 1-2 hrs
  • Peak effects: Variable
  • Duration of action: 8-24 hrs
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9
Q

Methylprednisolone Sodium Succinate (Solu-Medrol)

Special considerations

A
  • Preg Cat: C
  • Not effective for spinal cord injury greater than 8 hrs ago
  • May cross the placenta and cause fetal harm
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